Patents by Inventor Bridgitte Gicquel

Bridgitte Gicquel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated recombinant mycobacteria useful as immunogens or as vaccine components
    Publication number: 20010024653
    Abstract: This invention provides recombinant mycobacterium strains of pathogenic origin that have been attenuated by the inactivation of a gene coding for a metabolic protein, specifically a gene coding for a protein necessary for the biosynthesis of a purine or a pyrimidine base, and more precisely, the purC gene that codes for an enzyme of the metabolic pathway of purine biosynthesis. The recombinant mycobacterium of this invention have a reduced capacity to propagate in a mammalian host, but remain viable in the host for a period of time sufficient to induce an protective immune response against the natural pathogenic mycobacterium counterpart.
    Type: Application
    Filed: May 9, 2001
    Publication date: September 27, 2001
    Applicant: Institut Pasteur
    Inventors: Bridgitte Gicquel, Christophe Guilhot, Mary Jackson
  • Attenuated recombinant mycobacteria useful as immunogens or as vaccine components
    Patent number: 6261568
    Abstract: This invention provides recombinant mycobacterium strains of pathogenic origin that have been attenuated by the inactivation of a gene coding for a metabolic protein, specifically a gene coding for a protein necessary for the biosynthesis of a purine or a pyrimidine base, and more precisely, the purC gene that codes for an enzyme of the metabolic pathway of purine biosynthesis. The recombinant mycobacterium of this invention have a reduced capacity to propagate in a mammalian host, but remain viable in the host for a period of time sufficient to induce an protective immune response against the natural pathogenic mycobacterium counterpart.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: July 17, 2001
    Assignee: Institut Pasteur
    Inventors: Bridgitte Gicquel, Christophe Guilhot, Mary Jackson