Patents by Inventor Brigid Hogan

Brigid Hogan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR LUNG CELL EXPANSION AND DIFFERENTIATION
    Publication number: 20220380734
    Abstract: The present disclosure provides systems for growing and, modeling lung cells in organoid cultures and methods of using same.
    Type: Application
    Filed: September 28, 2020
    Publication date: December 1, 2022
    Applicant: DUKE UNIVERSITY
    Inventors: Purushothama Rao Tata, Brigid Hogan, Hiroaki Katsura
  • PLURIPOTENTIAL EMBRYONIC STEM CELLS AND METHODS OF MAKING SAME
    Publication number: 20070178590
    Abstract: The present invention provides a non-mouse, including human, pluripotential embryonic stem cell which can: (a) be maintained on feeder layers for at least 20 passages; and (b) give rise to embryoid bodies and multiple differentiated cell phenotypes in monolayer culture. The invention further provides a method of making a pluripotential embryonic stem cell comprising culturing germs cells and germ cell progenitors in a composition comprising a growth enhancing amount of basic fibroblast growth factor, leukemia inhibitory factor, membrane associated steel factor, and soluble steel factor to primordial germ cells under cell growth conditions, thereby making a pluripotential embryonic stem cell. Also provided are composition useful to produce the pluripotent embryonic stem cells and methods of screening associated with the method of making the embryonic stem cell.
    Type: Application
    Filed: October 18, 2006
    Publication date: August 2, 2007
    Inventor: Brigid Hogan
  • Compositions and Methods for Making Embryonic Stem Cells
    Publication number: 20060275898
    Abstract: The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein.
    Type: Application
    Filed: June 12, 2006
    Publication date: December 7, 2006
    Applicant: VANDERBILT UNIVERSITY
    Inventors: Brigid Hogan, Guang-Quan Zhao
  • Antibodies binding to polypeptides encoded by developmentally-regulated endothelial cell locus-1
    Patent number: 7041801
    Abstract: The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particularly, the invention related to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product. Since del-1 is expressed in endothelial cells and certain cancer cells, it may be useful as an endothelial cell and tumor marker. In addition, anti-Del-1 antibodies for immunological assessment of Del-1 protein expression as well as for inhibiting or stimulating Del-1 function are provided.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: May 9, 2006
    Inventors: Thomas Quertermous, Brigid Hogan, H. Ralph Snodgrass, Thomas Joel Zupancic
  • BMP-15 compositions
    Patent number: 6034229
    Abstract: Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: March 7, 2000
    Assignees: Genetics Institute, Inc., Vanderbilt University
    Inventors: Anthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan
  • Developmentally-regulated endothelial cell locus-1
    Patent number: 5877281
    Abstract: The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particular, the invention relates to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: March 2, 1999
    Assignees: Progenitor, Inc., Vanderbilt University
    Inventors: Thomas Quertermous, Brigid Hogan, H. Ralph Snodgrass, Thomas Joel Zupancic
  • BMP-15 compositions
    Patent number: 5728679
    Abstract: Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: March 17, 1998
    Assignees: Genetics Institute, Inc., Vanderbilt University
    Inventors: Anthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan
  • BMP-15 compositions
    Patent number: 5635372
    Abstract: Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 3, 1997
    Assignees: Genetics Institute, Inc., Vanderbilt University
    Inventors: Anthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan