Patents by Inventor Brigit E. Riley

Brigit E. Riley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CASSETTES OF ANTI-COMPLEMENT COMPONENT 3 ANTIBODY, VECTORIZATION AND THERAPUTIC APPLICATION
    Publication number: 20260043046
    Abstract: Provided herein are methods for expression of anti-C3 molecule by administering a recombinant adeno-associated virus (rAAV) virion in an amount capable of blocking C3 activity in the eye.
    Type: Application
    Filed: March 15, 2023
    Publication date: February 12, 2026
    Applicant: Adverum Biotechnologies, Inc.
    Inventors: Ruslan Grishanin, Jie Ma, Sing Ying Cheung, Kellie Schaefer-Swale, Brigit E. Riley
  • Clinical parameters by expression of factor VIII
    Patent number: 12497632
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: December 16, 2025
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Edward R. Conner, Brigit E. Riley, Didier Rouy
  • METHODS AND COMPOSITIONS FOR MODULATION OF TAU PROTEINS
    Publication number: 20250268981
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: April 24, 2025
    Publication date: August 28, 2025
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Bryan Zeitler
  • Methods and compositions for modulation of tau proteins
    Patent number: 12318427
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: June 3, 2025
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Bryan Zeitler
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RARE DISEASES
    Publication number: 20250099624
    Abstract: The present disclosure is in the field of modulation of genes involved in rare diseases including for diagnostics and therapeutics for rare diseases such as Angelman's Syndrome, Facioscapulohumeral Muscular Dystrophy (FHMD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD) and Spinal Muscular Atrophy (SMA).
    Type: Application
    Filed: March 19, 2024
    Publication date: March 27, 2025
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Michael C. HOLMES, Brigit E. RILEY, Thomas WECHSLER, Bryan ZEITLER, Lei ZHANG
  • Methods and compositions for engineering immunity
    Patent number: 11793888
    Abstract: Nucleases and methods of using these nucleases for expressing an antibody from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: October 24, 2023
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Michael C. Holmes, Brigit E. Riley
  • LIVER-SPECIFIC CONSTRUCTS, FACTOR VIII EXPRESSION CASSETTES AND METHODS OF USE THEREOF
    Publication number: 20230119850
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Application
    Filed: September 1, 2022
    Publication date: April 20, 2023
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Gary K. Lee
  • Liver-specific constructs factor VIII expression cassettes and methods of use thereof
    Patent number: 11452782
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: September 27, 2022
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Gary K. Lee
  • IMPROVED CLINICAL PARAMETERS BY EXPRESSION OF FACTOR VIII
    Publication number: 20210171982
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Application
    Filed: August 2, 2019
    Publication date: June 10, 2021
    Applicant: Sangamo Therapeutics, Inc.
    Inventors: Edward R. Conner, Brigit E. Riley, Didier Rouy
  • Liver-specific constructs and methods of use thereof
    Patent number: 10828376
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: November 10, 2020
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Gary K. Lee
  • METHODS AND COMPOSITIONS FOR ENGINEERING IMMUNITY
    Publication number: 20200282079
    Abstract: Nucleases and methods of using these nucleases for expressing an antibody from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 10, 2020
    Inventors: Michael C. Holmes, Brigit E. Riley
  • Methods and compositions for engineering immunity
    Patent number: 10639383
    Abstract: Nucleases and methods of using these nucleases for expressing an antibody from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 5, 2020
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Michael C. Holmes, Brigit E. Riley
  • DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
    Publication number: 20200102577
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Application
    Filed: September 6, 2019
    Publication date: April 2, 2020
    Inventors: GARY K. LEE, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR MODULATION OF TAU PROTEINS
    Publication number: 20200101133
    Abstract: The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 2, 2020
    Inventors: Brigit E. Riley, Bryan Zeitler
  • B-CELL ENGINEERING
    Publication number: 20190352614
    Abstract: Described herein are constructs used for B-cell genomic engineering and for expression of a transgene and/or for modulation of B cell function.
    Type: Application
    Filed: January 25, 2018
    Publication date: November 21, 2019
    Inventors: Rainier Amora, Michael C. Holmes, Brigit E. Riley
  • Delivery methods and compositions for nuclease-mediated genome engineering
    Patent number: 10450585
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: October 22, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Gary K. Lee, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RARE DISEASES
    Publication number: 20190167815
    Abstract: The present disclosure is in the field of modulation of genes involved in rare diseases including for diagnostics and therapeutics for rare diseases such as Angelman's Syndrome, Facioscapulohumeral Muscular Dystrophy (FHMD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD) and Spinal Muscular Atrophy (SMA).
    Type: Application
    Filed: October 24, 2018
    Publication date: June 6, 2019
    Inventors: Michael C. Holmes, Brigit E. Riley, Thomas Wechsler, Bryan Zeitler, Lei Zhang
  • LIVER-SPECIFIC CONSTRUCTS, FACTOR VIII EXPRESSION CASSETTES AND METHODS OF USE THEREOF
    Publication number: 20190151472
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 23, 2019
    Inventors: Brigit E. Riley, Gary K. Lee
  • LIVER-SPECIFIC CONSTRUCTS AND METHODS OF USE THEREOF
    Publication number: 20190142970
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Application
    Filed: October 18, 2018
    Publication date: May 16, 2019
    Inventors: Brigit E. Riley, Gary K. Lee
  • Liver-specific constructs, factor VIII expression cassettes and methods of use thereof
    Patent number: 10143760
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: December 4, 2018
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Gary K. Lee