Patents by Inventor Brigit Riley

Brigit Riley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying modulators of ubiquitin ligases
    Patent number: 9464311
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: October 11, 2016
    Assignee: E3X Bio, Inc.
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans
  • METHOD FOR IDENTIFYING MODULATORS OF UBIQUITIN LIGASES
    Publication number: 20140327158
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: E3X BIO
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans