Patents by Inventor Brigit Riley

Brigit Riley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for trans-splicing utilizing trifunctional elements
    Patent number: 12686869
    Abstract: The present disclosure provides a trans-splicing molecule that has a trifunctional element suitable for targeted trans-splicing of an RNA or pre-mRNA molecule.
    Type: Grant
    Filed: January 23, 2026
    Date of Patent: July 21, 2026
    Assignee: Amber Bio Inc.
    Inventors: Jacob Borrajo, Brigit Riley, Kamyab Javanmardi, Patricia Biezonski, Samuel Demario
  • AAV VARIANTS FOR THE TREATMENT OF DRY AMD
    Publication number: 20260199522
    Abstract: Provided is the intravitreal administration of recombinant adeno-associated virus (rAAV)-based gene therapies for the amelioration of dry-AMD related symptoms, prevention of dry-AMD and treatment of dry-AMD.
    Type: Application
    Filed: November 28, 2023
    Publication date: July 16, 2026
    Inventors: Ruslan Grishanin, Gustavo De Alencastro, Brigit Riley
  • Methods and compositions for trans-splicing utilizing small nuclear RNAs and small nucleolar RNAs
    Patent number: 12655424
    Abstract: The present disclosure provides compositions and methods of use thereof for targeting trans-splicing of a pre-mRNA in a cell utilizing small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), and related methods.
    Type: Grant
    Filed: November 5, 2024
    Date of Patent: June 16, 2026
    Assignee: Amber Bio Inc.
    Inventors: Jacob Borrajo, Sam Demario, Kamyab Javanmardi, David Yao, Brigit Riley
  • METHODS AND COMPOSITIONS FOR TRANS-SPLICING UTILIZING SMALL NUCLEAR RNAS AND SMALL NUCLEOLAR RNAS
    Publication number: 20250250563
    Abstract: The present disclosure provides compositions and methods of use thereof for targeting trans-splicing of a pre-mRNA in a cell utilizing small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), and related methods.
    Type: Application
    Filed: November 5, 2024
    Publication date: August 7, 2025
    Inventors: Jacob BORRAJO, Sam DEMARIO, Kamyab JAVANMARDI, David Yao, Brigit Riley
  • METHODS OF TREATING OCULAR NEOVASCULAR DISEASES USING AAV2 VARIANTS ENCODING AFLIBERCEPT
    Publication number: 20250137011
    Abstract: Provided are methods for treating an ocular neovascular disease in an individual, comprising administering a unit dose of recombinant adeno-associated virus (rAAV) particles to an eye of the individual, wherein the rAAV particles comprise: a) a nucleic acid encoding a polypeptide comprising an amino acid sequence with at least about 95% identity to the amino acid sequence of SEQ ID NO: 35 and flanked by AAV2 inverted terminal repeats (ITRs), and b) an AAV2 capsid protein comprising an amino acid sequence LGETTRP (SEQ ID NO: 14) inserted between positions 587 and 588 of the capsid protein, wherein the amino acid residue numbering corresponds to an AAV2 VP1 capsid protein.
    Type: Application
    Filed: February 1, 2023
    Publication date: May 1, 2025
    Applicant: Adverum Biotechnologies, Inc.
    Inventors: Kelly Hanna, Kellie Schaefer-Swale, Brigit Riley, Ruslan Grishanin, Adam Turpcu, Richard Beckman
  • Method for identifying modulators of ubiquitin ligases
    Patent number: 9464311
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: October 11, 2016
    Assignee: E3X Bio, Inc.
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans
  • METHOD FOR IDENTIFYING MODULATORS OF UBIQUITIN LIGASES
    Publication number: 20140327158
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: E3X BIO
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans