Patents by Inventor Brigitte Biesinger-Zwosta

Brigitte Biesinger-Zwosta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri (H. saimiri) subgroup C
    Patent number: 5670352
    Abstract: The invention concerns the transformation of human T-lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed cells grow independently of antigen stimulation and can have a phenotype of activated mature T-lymphocytes, expressing cell surface markers characteristic for the distinct differentiation status of the T-cells. Infection with strains of H. saimiri belonging to the subgroups above can thus be used to generate human T-cell lines for a variety of immunological and biochemical applications as well as for therapeutic use.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: September 23, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Brigitte Biesinger-Zwosta, Ingrid Mueller-Fleckenstein, Bernhard W. Fleckenstein
  • Use of lymphocytes transformed with herpesvirus saimiri in a process for replicating viruses of the HIV type which cause immune deficiency
    Patent number: 5656475
    Abstract: A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 12, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Sigrid Nick, Helmut Fickenscher, Brigitte Biesinger-Zwosta, Gerhard Jahn, Bernhard Fleckenstein