Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: Diagnostic patches and bracelets for promoting personal and community health including related processes, methods, and systems are directed to fever patches and fever bracelets for school and university health and wellness including mitigation of the spread of infectious diseases and contact tracing during an epidemic or pandemic. Other populations addressed by these methods include nursing homes, office buildings, and factories as well as the general citizenry of entire cities, counties, states, and even countries at large. Further apparatus and devices include disease detection patches and disease detection bracelets for identifying the onset of an infection and for detecting the present of antibodies to such infectious diseases. Related mitigation and contact methods for several different addressed groups and large populations are also provided for these disease detection patches and bracelets.

Abstract: Devices, methods and systems related to wearable patch having blood alcohol content detector. In some embodiments, a wearable patch can include a patch structure having one or more layers and configured to allow the patch to be worn by a user, and an analyzer component implemented on or at least partially within the patch structure and configured to measure alcohol content level in the user. The wearable patch can further include an interface component implemented on or at least partially within the patch structure and in communication with the analyzer component, with the interface component being configured to provide a notification based on the measured alcohol content. In some embodiments, such a wearable patch can be a part of a system such as a monitoring system or a compliance system.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by trans-dermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

Abstract: A personal diagnostic patch device for biological analysis includes a sample acquisition layer for obtaining a fluid sample, a fluidic processing layer including a fluidic circuit for directing fluid flow, an assay results detection layer having a detector for detecting diagnostic results derived from fluid sample analysis, and a processor and transmitter for sending diagnostic results to a remote location. The layers are situated in register with each other and operatively attached with constituent elements in alignment to form the fluidic circuit for sample processing, detection, and analysis. Related systems include a remotely located user computer for receiving a signal from the patch device when the device is provided with the transmitter. The user computer may be connected to a network including any one or more of several different medical providers. Methods include use of the patch device for specific applications, related processes, and steps for manufacturing and assembling.

Abstract: The present invention relates in general to molecular and cellular biomagnetic assays and, in particular, to molecular and cellular biomagnetic assays conducted on magneto-optical bio-discs. The invention further relates to magneto-optical bio-disc systems including the magneto-optical bio-discs and MO drives. More specifically, but without restriction to the particular embodiments hereinafter described in accordance with the best mode of practice, this invention relates to biomagnetic methods, including immunomagnetic methods, for detection and selective manipulation of specific target cells in cell populations and solutions of cell populations, using magnetic particles or beads, and to magnetically guided neurite growth, nerve regeneration, and magnetically formed neural networks using the MOBDS.

Abstract: Methods for decreasing non-specific bindings of beads in dual bead assays and related optical bio-discs and disc drive systems. Methods include identifying whether a target agent is present in a biological sample and mixing capture beads each having at least one transport probe affixed thereto, reporter beads each having at least one signal probe affixed thereto, and a biological sample. Mixing is performed under binding conditions to permit formation of a dual bead complex if the target agent is present in the sample. The reporter bead and capture bead each are bound to the target agent. Denaturing the target agent and keeping it in the denatured form by use of a specialized hybridization buffer is also provided. A denaturing agent is guanidine isothiocynate.

Abstract: The invention provides compositions and methods for determining whether a target agent is present in a biological sample. The invention provides a sensitive and consumer friendly system for performing biological assays. More particularly, the invention is directed to the use of a biodisc in a dual bead assay designed to identify the presence of a target molecule. The invention further provides methods to optimize the selection of a suitable solid phase for use in a dual bead assay.

Abstract: Methods for deceasing non-specific bindings of beads in dual bead assays and related optical bio-discs and disc drive systems. The methods include determining the suitability of a test solid phase for purposes of use in a dual bead assay. The method also includes identifying whether a target agent is present in a biological sample and involves mixing capture beads, reporter beads, and a biological sample. The mixing is performed under binding conditions to permit formation of a dual bead complex if the target agent is present in the sample. The reporter bead and capture bead are each bound to the target agent. Cleavable spacers or displacement linkers may be used in forming the dual bead complexes. The methods also include placing the capture beads and the reporter beads spatially proximally, performing a ligation reaction employing a ligase, and isolating the dual bead complex from the mixture to obtain the isolate.

Abstract: Methods for decreasing non-specific bindings of beads in dual bead assays and related optical bio-discs and disc drive systems. The methods are employed to determine the suitability of a test solid phase for use in a dual bead assay. The methods include identifying whether a target agent is present in a biological sample and involve mixing capture beads, each having at least one transport probe affixed thereto. Reporter beads each have at least one signal probe affixed thereto. The reporter and capture beads are each bound to the target agent. The methods further include isolating the dual bead complex from the mixture to obtain an isolate, and exposing the isolate to a capture field on a disc. Detecting the presence of the dual bead complex in the disc is then performed to determine whether the target agent is present in the sample.

Abstract: The invention provides for methods of conjugating biochemical probes onto a solid phase for use in biomedical assays as implemented in conjunction with an optical bio-disc system. The method includes determining the suitability of a test solid phase for purposes of use in a dual bead assay, selecting a test solid phase, conjugating a probe to the test solid phase in the presence or absence of a cross-linking agent, and determining the total amount of probe bound to the test solid phase in the presence or absence of a cross-linking agent. The method is further employed to determine the percentage of probe bound covalently or non-covalently to the solid phase and calculating the percentage of probe bound covalently thereby selecting the solid phase with the highest conjugation efficiency. The invention is further directed at methods for determining whether a target agent is present in a biological sample. A bio-disc for performing a dual bead assay according to these methods is also provided.