Abstract: The invention refers to a method for culturing cells in a substrate in which a chamber having at least one side wall, a bottom, and a top is formed, comprising introduction of cells into the chamber, tilting of the substrate such that the cells accumulate on a side wall of the chamber, and holding the substrate in the tilted orientation such that the cells form a three-dimensional cell aggregate.

Abstract: A cooling pad (10) for medical or veterinary applications, the cooling pad comprising a first heat exchanger (20); a second heat exchanger (30), a heat transfer fluid; a piping system (40); and an integrated pump device (50) for the heat transfer fluid; wherein the first heat exchanger (20) and the second heat exchanger (30) have the heat transfer fluid flowing through them; wherein the piping system (40) fluidically connects the first heat exchanger and the second heat exchanger; wherein the pump device (50) is adapted to cause an exchange of the heat transfer fluid between the first heat exchanger and the second heat exchanger; wherein the cooling pad (10) comprises a hermetically sealed fluid circuit for the heat transfer fluid, the fluid circuit comprising the first heat exchanger (20), the second heat exchanger (30), the piping system (40) and the pump device (50). Further, a corresponding cooling device (60), cooling system (1) and corresponding method (200) are proposed.

Abstract: A system for carrying out analyses on and/or with biological sample material present in a sample arrangement region of a microfluidic sample chip comprises a connector plate for receiving the sample chip and a control unit to which the connector plate is detachably connectable for exchange of fluids and electrical signals.

Abstract: The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions.

Abstract: A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26).

Abstract: The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions.

Abstract: A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26).