Patents by Inventor Brittany L. Nairn

Brittany L. Nairn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput fluorescent screening assay for inhibitors of gram-negative bacterial iron uptake
    Patent number: 10604782
    Abstract: A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a candidate compound with an engineered Gram-negative bacteria in the presence of iron for a sufficient period of time, exposing the reaction solution to an energy source to generate the detectable signal, and detecting changes in the detectable signal in the reaction solution over time. The engineered Gram-negative bacteria comprises an iron transport protein on its outer membrane that comprises an amino acid residue that has been engineered with a detectable label that generates a detectable signal. The changes in the detectable signal in the assay system over time correspond to the effect of the candidate compound on iron transport in the Gram-negative bacteria.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 31, 2020
    Assignee: Kansas State University Research Foundation
    Inventors: Phillip E. Klebba, Salete M. Newton, Brittany L. Nairn, Mathew Hanson
  • HIGH-THROUGHPUT FLUORESCENT SCREENING ASSAY FOR INHIBITORS OF GRAM-NEGATIVE BACTERIAL IRON UPTAKE
    Publication number: 20180187236
    Abstract: A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a candidate compound with an engineered Gram-negative bacteria in the presence of iron for a sufficient period of time, exposing the reaction solution to an energy source to generate the detectable signal, and detecting changes in the detectable signal in the reaction solution over time. The engineered Gram-negative bacteria comprises an iron transport protein on its outer membrane that comprises an amino acid residue that has been engineered with a detectable label that generates a detectable signal. The changes in the detectable signal in the assay system over time correspond to the effect of the candidate compound on iron transport in the Gram-negative bacteria.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 5, 2018
    Inventors: Phillip E. Klebba, Salete M. Newton, Brittany L. Nairn, Mathew Hanson