Patents by Inventor Brittney L. Gurda

Brittney L. Gurda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SECRETABLE PROTEIN INDUCED IMMUNE TOLERIZATION AND TREATMENT OF AUTOIMMUNE, ALLERGIC AND OTHER DISEASES AND DISORDERS
    Publication number: 20230040275
    Abstract: Nucleic acids encoding fusion proteins that contain an unwanted antigen and a leader sequence for cell secretion are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat autoimmune, allergic and other diseases and disorders, such as multiple sclerosis.
    Type: Application
    Filed: November 19, 2020
    Publication date: February 9, 2023
    Applicant: SPARK THERAPEUTICS, INC.
    Inventors: David William ANDERSON, Brittney L. GURDA, Federico MINGOZZI, Mustafa N. YAZICIOGLU, William QUINN
  • COMPOSITIONS AND METHODS FOR TREATING MPSI
    Publication number: 20200397872
    Abstract: A vector have an expression cassette containing have a hIDUA gene has a sequence of SEQ ID NO: 1 (FIG. 1) or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be a production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 24, 2020
    Inventors: James M. Wilson, Brittney L. Gurda
  • Compositions and methods for treating MPSI
    Patent number: 10792343
    Abstract: A vector have an expression cassette containing have a hIDUA gene has a sequence of SEQ ID NO: 1 (FIG. 1) or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be a production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: October 6, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Brittney L. Gurda
  • COMPOSITIONS AND METHODS FOR TREATING MPSI
    Publication number: 20190111116
    Abstract: A vector have an expression cassette containing have a hIDUA gene has a sequence of SEQ ID NO: 1 (FIG. 1) or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be a production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 18, 2019
    Inventors: James M. Wilson, Brittney L. Gurda
  • Compositions and methods for treating MPSI
    Patent number: 10137176
    Abstract: A vector having an expression cassette having a hIDUA gene having a sequence of SEQ ID NO: 1 or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurle-Scheie and Scheie syndromes.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 27, 2018
    Assignee: The Trustee of the University of Pennsylvania
    Inventors: James M. Wilson, Brittney L. Gurda
  • COMPOSITIONS AND METHODS FOR TREATING MPSI
    Publication number: 20160000887
    Abstract: A vector having an expression cassette having a hIDUA gene having a sequence of SEQ ID NO: 1 or a sequence at least about 95% identical thereto which encodes a functional human alpha-L-iduronidase is provided. The vector may be production vector or a rAAV8. Also provided are compositions containing these vectors and methods of treating MPSI and the symptoms associated with Hurler, Hurle-Scheie and Scheie syndromes.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 7, 2016
    Inventors: James M. Wilson, Brittney L. Gurda