Patents by Inventor Broc Flores

Broc Flores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiolabeled PDE10 inhibitors
    Patent number: 8846000
    Abstract: The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: September 30, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christopher D. Cox, Broc A. Flores, Eric Hostetler, Hong Fan
  • 2,5-disubstituted morpholine orexin receptor antagonists
    Patent number: 8466281
    Abstract: The present invention is directed to 2,5-disubstituted morpholine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: June 18, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Paul J. Coleman, Christopher D. Cox, Broc Flores, John D. Schreier
  • 2,3-disubstituted piperidine orexin receptor antagonists
    Patent number: 8357700
    Abstract: The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: January 22, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christopher D. Cox, Broc Flores, John D. Schreier
  • RADIOLABELED PDE10 INHIBITORS
    Publication number: 20120064005
    Abstract: The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 15, 2012
    Inventors: Christopher Cox, Broc A. Flores, Eric Hostetler, Hong Fan
  • 7-AZA-QUINAZOLINE PDE10 INHIBITORS
    Publication number: 20110319409
    Abstract: The present invention is directed to 7-aza-quinazoline compounds of general structural formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10).
    Type: Application
    Filed: June 23, 2010
    Publication date: December 29, 2011
    Inventors: Christopher D. Cox, Izzat T. Raheem, Broc A. Flores, David B. Whitman
  • 2,5-Disubstituted Morpholine Orexin REceptor Antagonists
    Publication number: 20110312961
    Abstract: The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
    Type: Application
    Filed: October 15, 2009
    Publication date: December 22, 2011
    Inventors: Christopher D. Cox, Paul J. Coleman, Broc Flores, John D. Schreier
  • 2,3-Disubstituted Piperidine Orexin Receptor Antagonists
    Publication number: 20110263643
    Abstract: The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Application
    Filed: October 15, 2009
    Publication date: October 27, 2011
    Inventors: Christopher D. Cox, Broc Flores, John D. Schreier