Patents by Inventor Brook Ragle

Brook Ragle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions related to immunizing against lung disease and conditions
    Patent number: 8840906
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: September 23, 2014
    Assignee: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind, Brook Ragle
  • Methods and Compositions Related to Immunizing Against Staphylococcal Lung Diseases and Conditions
    Publication number: 20110027265
    Abstract: Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
    Type: Application
    Filed: August 29, 2008
    Publication date: February 3, 2011
    Applicant: The University of Chicago
    Inventors: Juliane Bubeck-Wardenburg, Olaf Schneewind, Brook Ragle