Patents by Inventor Brooke B. Ancrile

Brooke B. Ancrile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating oncogenic Ras driven cancers
    Patent number: 8927598
    Abstract: Oncogenic Ras-driven cancer is treated with agent by interrupting pathway comprising activation of Akt by oncogenic Ras, activated Akt causing phosphorylation of eNOS at S1177 site of eNOS to provide activated eNOS in cancer cells and activated eNOS causing activation of wildtype Ras by nitrosylation thereof at C118 to provide GTP-bound activated wildtype H and N Ras. L-NAME can be orally administered to interrupt this pathway. Wortmannin can be administered intravenously to interrupt this pathway. Novel siRNAs are disclosed useful to interrupt said pathway.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: January 6, 2015
    Assignee: Duke University
    Inventors: Christopher M. Counter, Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus