Patents by Inventor Brooke Emerling
Brooke Emerling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9493813Abstract: The invention features methods for identifying compounds that modulate the activity of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). Inhibitors of PI5P4K can be used in, for example, the treatment or prevention of cell proliferation disorders (e.g., the prevention of tumor cell growth in p53 mutated cancers).Type: GrantFiled: January 13, 2012Date of Patent: November 15, 2016Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Brooke Emerling, Atsuo Sasaki, Lewis C. Cantley, Jonathan Hurov
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Publication number: 20140080893Abstract: The invention features methods for identifying compounds that modulate the activity of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) Inhibitors of PI5P4K can be used in, for example, the treatment or prevention of cell proliferation dis orders (e.g., the prevention of tumor cell growth in p53 mutated cancers).Type: ApplicationFiled: January 13, 2012Publication date: March 20, 2014Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: Brooke Emerling, Atsuo Sasaki, Lewis C. Cantley, Jonathan Hurov
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Publication number: 20070276126Abstract: Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.Type: ApplicationFiled: August 12, 2003Publication date: November 29, 2007Inventors: Vicki Elliott, Reena Khare, Brooke Emerling, Amy Kable, Uyen Tran, Pei Jin, Shanya Becha, Joseph Marquis, Anita Swarnakar, Narinder Chawla, Jayalaxmi Ramkumar, April Hafalia, Soo Lee, Xin Jiang, Alan Jackson, Thomas Richardson, Julie Blake, Jonathan Wang, David Chien, Yonghong Yang
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Publication number: 20070225218Abstract: Various embodiments of the invention provide human extracellular messengers (EXMES) and polynucleotides which identify and encode EXMES. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of EXMES.Type: ApplicationFiled: June 26, 2002Publication date: September 27, 2007Inventors: Angelo Delegeane, Mark Borowsky, Farrah Khan, Liam Kearney, Jayalaxmi Ramkumar, Narinder Chawla, Yan Lu, Cynthia Honchell, Deborah kallick, Brooke Emerling, Ann Gorvard, Jennifer Griffin, Bridget Warren, Henry Yue, Kavitha Thangavelu, William Sprague, Craig Ison, Vicki Elliott, Patricia Lehr-Mason, Thomas Richardson, Uyen Tran, Anita Swarnakar, Pei Jin, Amy Kable
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Publication number: 20070124581Abstract: Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.Type: ApplicationFiled: May 6, 2003Publication date: May 31, 2007Inventors: Reena Khare, Vicki Elliott, Joseph Marquis, Jayalaxmi Ramkumar, Narinder Chawla, Patricia Mason, April Hafalia, Anita Swarnakar, Pei Jin, Shanya Becha, Amy Kable, Uyen Tran, Mariah Baughn, Neil Burford, Richard Graul, Brooke Emerling, William Sprague, Jennifer Griffin, Craig Ison
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Publication number: 20070065820Abstract: Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM.Type: ApplicationFiled: November 10, 2003Publication date: March 22, 2007Inventors: Xin Jiang, Shanya Becha, Sean Bulloch, Hsin-Ru Chang, Narinder Chawla, Vicki Elliott, Brooke Emerling, Kimberly Gietzen, April Hafalia, Alan Jackson, Amy Kable, Reena Khare, Soo Lee, Joseph Marquis, Jagi Murage, Anita Swarnakar, Yonghong Yang
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Publication number: 20060216706Abstract: Various embodiments of the invention provide human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.Type: ApplicationFiled: July 16, 2002Publication date: September 28, 2006Inventors: Y Tang, Vicki Elliott, Mariah Baughn, Henry Yue, Aaron Klammer, April Hafalia, Elizabeth Stewart, Cynthia Honchell, Ann Gorvard, Ian Forsythe, Li Ding, Uyen Tran, Jennifer Griffin, Yeganeh Zebarjadian, Anna Chinn, Anne Curtis, Mark Borowsky, Anita Swarnakar, Neil Burford, Wen Luo, Ernestine Lee, Brooke Emerling, Soo Lee, Junming Yang, Farrah Khan, Jayalaxmi Ramkumar, Yan Lu, Narinder Chawla, Brendan Duggan, Kimberly Gietzen, Karen Jones
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Publication number: 20060194275Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.Type: ApplicationFiled: April 12, 2002Publication date: August 31, 2006Applicant: INCYTE CORPORATIONInventors: Mariah Baughn, Vicki Elliott, April Hafalia, Junming Yang, Narinder Chawla, Jayalaxmi Ramkumar, Ian Forsythe, Yan Lu, Y Tom Tang, Henry Yue, Brigitte Raumann, Preeti Lal, Yalda Azimzai, Dyung Lu, Ameena Gandhi, Michael Thornton, Danniel Nguyen, Chandra Arvizu, Brooke Emerling, Anita Swarnakar, Monique Yao, Li Ding, Ann He, Jennifer Griffin, Madhusudan Sanjanwala, Kimberly Gietzen, Ernestine Lee, Yuming Xu, Janice Au-Young, Debopriya Das, Soo Lee, Hsin-Ru Chang
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Publication number: 20060127894Abstract: Various embodiments of the invention provide human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.Type: ApplicationFiled: August 8, 2002Publication date: June 15, 2006Applicant: Incyte CorporationInventors: Yalda Azimzai, Ines Barroso, Mariah Baughn, Shanya Becha, Mark Borowsky, Brendan Duggan, Vicki Elliott, Brooke Emerling, Ian Forsythe, Kimberly Gietzen, Ann Gorvad, Richard Graul, Jennifer Griffin, Rajagopal Gururajan, April Hafalia, Craig Ison, Amy Kable, Farrah Khan, Sally Lee, Soo Lee, Joana Li, Roopa Reddy, Thomas Richardson, William Sprague, Anita Swarnakar, Y. Tom Tang, Bridget Warren, Yuming Xu, Monique Yao, Henry Yue, Huibin Yue
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Publication number: 20060115813Abstract: Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.Type: ApplicationFiled: June 6, 2002Publication date: June 1, 2006Applicant: INCYTE CORPORATIONInventors: Junming Yang, Brooke Emerling, Y Tang, Mariah Baugh, Ernestine Lee, Jayalaxmi Ramkumar, Henry Yue, Jennifer Griffin, Narinder Chawla, Bao Tran, Danniel Nguyen, Farrah Khan, Ameena Gandhi, April Hafalia, Anita Swarnakar, Rajagopal Gururajan, Jennifer Policky, Monique Yao, Bridget Warren, Kimberly Gietzen, Vicki Elliott, Soo Lee, Bharati Sanjanwala, Cynthia Honchell, Ian Forsythe, Ann Gorvad, Thomas Richardson, Sally Lee, Ines Barroso
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Publication number: 20060051836Abstract: Various embodiments of the invention provide human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.Type: ApplicationFiled: October 10, 2002Publication date: March 9, 2006Inventors: Y Tang, Ian Forsythe, Brooke Emerling, April Hafalia, Henry Yue, Kimberly Gietzen, Narinder Chawla, Joseph Marquis, Shanya Becha, Amy Kable, Preeti Lal, Thomas Richardson, Soo Lee, Ernestine Lee, Bao Tran
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Publication number: 20050191627Abstract: Various embodiments of the invention provide human enzymes (ENZM) and polynucleotides which identify and encode ENZM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ENZM.Type: ApplicationFiled: September 26, 2002Publication date: September 1, 2005Applicant: Incyte CorporationInventors: Junming Yang, Aina Dyung Lu, Henry Yue, Vicki Elliott, Bridget Warren, Brendan Duggan, Ian Forsythe, Ernestine Lee, April Hafalia, Jayalaxmi Ramkumar, Narinder Chawla, Mariah Baughn, Shanya Becha, Ann Gorvad, Uyen Tran, Joana Li, Monique Yao, Craig Ison, Jennifer Griffin, Soo Lee, Hsin-Ru Chang, Brooke Emerling, Tom Tang, Preeti Lal, Amy Kable, Joseph Marquis, Xin Jiang, Alan Jackson, Yeganeh Zebarjadian, Anita Swarnakar, Amy Wilson, Pei Jin, Thomas Richardson, Umesh Bhatia, John Burrill, Sally Lee, Julie Blake, Anne Ho, Wenjin Zheng, Jin Gao
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Publication number: 20050186569Abstract: A Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.Type: ApplicationFiled: October 29, 2002Publication date: August 25, 2005Inventors: Shanya Becha, Mark Borowsky, Neil Burford, Narinder Chawla, Vicki Elliott, Brooke Emerling, Ian Forsythe, Kimberly Gietzen, Ann Gorvad, Jennifer Griffin, April Hafalia, Craig Ison, Preeti Lal, Ernestine Lee, Sally Lee, Soo Lee, Joseph Marquis, Jayalaxmi Ramkumar, William Sprague, Anita Swarnakar, Y. Tang, Bridget Warren, Junming Yang, Henry Yue, Yeganeh Zebarjadian
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Publication number: 20050186568Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: ApplicationFiled: October 17, 2002Publication date: August 25, 2005Inventors: Olga Bandman, Mariah Baughn, Shanya Becha, Mark Borowsky, Brendan Duggan, Brooke Emerling, Ian Forsythe, Ameena Ganhi, Jennifer Griffin, Rajagopal Gururajan, April Hafalia, Farrah Khan, Preeti Lal, Ernestine Lee, Soo Lee, Erika Lindquist, Dyung Aina Lu, Yan Lu, Joseph Marquis, Danniel Nguyen, Chandra Arvizu, Jayalaxmi Ramkumar, Shirley Recipon, Thomas Richardson, Anita Swarnakar, Y.Tom Tang, Michael Thornton, Uyen Tran, Narinder Chawla, Bridget Warren, Junming Yang, Monique Yao, Henry Yue, Yeganeh Zebarjadian
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Publication number: 20050176944Abstract: Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.Type: ApplicationFiled: August 16, 2002Publication date: August 11, 2005Inventors: Henry Yue, Dyung Lu, Anita Swarnakar, Y. Tang, Jennifer Griffin, Brooke Emerling, Ian Forsythe, Monique Yao, Jayalaxmi Ramkumar, Thomas Richardson, Shanya Becha, Ernestine Lee, Bridget Warren, Patricia Lehr-Mason, Mariah Baughn, Joana Li, Brendan Duggan, Kimberly Gietzen, Preeti Lal, Mark Borowsky, Craig Ison, Kavitha Thangavelu, Yuming Xu, Sally Lee, Vicki Elliott, William Sprague, Yalda Azimzai, April Hafalia, Li Ding, Danniel Nguyen, Cynthia Honchell, Wen Luo, Narinder Chawla, Joseph Marquis, Jennifer Jackson, Uyen Tran
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Publication number: 20050130145Abstract: Various embodiments of the invention provide human secreted proteins (SECP) and polynucleotides which identify and encode SECP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.Type: ApplicationFiled: October 3, 2002Publication date: June 16, 2005Inventors: Henry Yue, Bridget Warren, Patricia Lehr-Mason, Uyen Tran, Brendan Duggan, Kavitha Thangavelu, Junming Yang, Yuming Xu, Y. Tang, Narinder Chawla, Vicki Elliott, Ian Forsythe, Shanya Becha, Monique Yao, Brooke Emerling, Jennifer Griffin, Preeti Lal, Yeganeh Zebarjadian, Mariah Baughn, Ernestine Lee, Soo Lee, Jayalaxmi Ramkumar, Ann Gorvad, Amy Kable, Dyung Lu, Mark Borowsky
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Publication number: 20050123912Abstract: Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.Type: ApplicationFiled: August 14, 2002Publication date: June 9, 2005Inventors: Ines Barroso, Mariah Baughn, Shanya Becha, Julie Blake, Mark Borowsky, Neil Burford, Brendan Duggan, Vicki Elliott, Brooke Emerling, Ian Forsythe, Kimberly Gietzen, Ann Gorvad, Jennifer Griffin, April Hafalia, Cynthia Honchell, Craig Ison, Farrah Khan, Preeti Lal, Ernestine Lee, Sally Lee, Soo Lee, Joana Li, Dyung Lu, Yan Lu, Patricia Lehr-Mason, Danniel Nguyen, Jayalaxmi Ramkumar, William Sprague, Y Tang, Kavitha Thangavelu, Michael Thornton, Uyen Tran, Narinder Chawla, Bridget Warren, Yuming Xu, Monique Yao, Henry Yue, Huibin Yue, Yeganeh Zebarjadian
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Publication number: 20050118582Abstract: Various embodiments of the invention provide human nucleic acid-associated proteins (NAAP) and polynucleotides which identify and encode NAAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of NAAP.Type: ApplicationFiled: July 10, 2002Publication date: June 2, 2005Inventors: Anita Swarnakar, Thomas Richardson, Bridget Warren, Jennifer Griffin, Y Tang, Henry Yue, Mariah Baughn, Brooke Emerling, Preeti Lal, Dyung Lu, Ian Forsythe, Jayalaxmi Ramkumar, Joana Li, Shanya Becha, Brendan Duggan, Madhusudan Sanjanwala, Ernestine Lee, Neil Burford, Vicki Elliott, Craig Ison, Li Ding, Mark Borowsky, Monique Yao, Ines Barroso, Bao Tran, Narinder Chawla, April Hafalia, Danniel Nguyen, Yan Lu, Chandra Arvizu
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Publication number: 20050118594Abstract: Various embodiments of the invention provide human enzymes (ENZM) and polynucleotides which identify and encode-ENZM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ENZM.Type: ApplicationFiled: December 12, 2002Publication date: June 2, 2005Inventors: Narinder Chawla, Soo Lee, Huijun Ring, Ernestine Lee, Ian Forsythe, Reena Khare, Uyen Tran, Amy Kable, Thomas Richardson, Brooke Emerling, Erika Lindquist, Mariah Baughn, April Hafalia, Pei Jin, Anita Swarnakar, Joana Li, Joseph Marquis, Ann Gorvad, William Sprague, Shanya Becha, Vicki Elliott
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Publication number: 20050107293Abstract: Various embodiments of the invention provide human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.a.Type: ApplicationFiled: September 13, 2002Publication date: May 19, 2005Inventors: William Sprague, Narinder Chawla, Bridget Warren, Y. Tom Tang, Vicki Elliott, Joseph Marquis, Joana Li, Jennifer Griffin, Kimberly Gietzen, Junming Yang, Dyung Lu, Brooke Emerling, Brendan Duggan, Thomas Richardson, Soo Lee, Jayalaxmi Ramkumar, Shanya Becha, Patricia Mason, Anita Swarnakar, Uyen Tran, Amy Kable, April Hafalia, Reena Khare