Abstract: The present invention provides methods for interfacing computer technology with biological and chemical processing and synthesis equipment. In preferred embodiments, the present invention features methods for the computer to interface with equipment useful for biological and chemical processing and synthesis in a remote manner.

Abstract: A circuit and method for estimating gradients of a target function using noise injection and correlation is provided. In one embodiment, an input signal is combined with an input noise signal and the combined signal is input to a circuit which computes the output of the target function. An amplified noise signal and output signal of the target function are input to a multiplier which performs a correlation of the inputs. The output of the multiplier is processed by a low-pass filter which generates the gradient. The circuit and method can be expanded to N-dimensions. Furthermore, in a alternate embodiment, a differentiator is coupled between the multiplier and amplifier and the multiplier and the output of the target function to differentiate the two signals prior to input to the multiplier. In other embodiments, the circuit may be used to compute gradient-like signals, wherein each component of the gradient is individually scaled by a different value.