Patents by Inventor Bror A. Thalen

Bror A. Thalen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5215979
    Abstract: The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms.The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: June 1, 1993
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Ralph L. Brattsand, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4950659
    Abstract: The invention refers to compounds having anti-inflamatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bondX.sub.1 is selected from hydrogen, fluorine, chlorine and bromineX.sub.2 is selected from hydrogen, fluorine, chlorine and bromineR.sub.1 is selected from hydrogen or a straight or branched hydrocarbon chain having 1-4 carbon atomsR.sub.2 is selected from hydrogen or straight and branched hydrocarbon chains having 1-10 carbon atoms andR.sub.3 is selected from ##STR2## is O or S R.sub.4 is selected from hydrogen, straight or branched hydrocarbon chains having 1-10 carbon atoms or from phenylR.sub.5 is selected from hydrogen or methyl andR.sub.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: August 21, 1990
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4820700
    Abstract: The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents in the carbon atom at position 20, in which formula the 1,2 position is saturated or is a double bond,X.sub.1 is hydrogen, fluorine, chlorine or bromine,X.sub.2 is hydrogen, fluorine, chlorine or bromine,R.sub.1 is hydrogen or methyl,R.sub.2 is a straight or branched hydrocarbon chain having 1-10 carbon atoms andR.sub.3 is hydrogen or a straight or branched chain alkyl group having 1-12 carbon atoms, a lower alkyl group substituted by 1-5 halogen atoms or an unsubstituted or substituted phenyl or benzyl group,provided that when R.sub.1 is methyl R.sub.2 is a hydrocarbon chain having 2-10 carbon atoms.
    Type: Grant
    Filed: January 5, 1987
    Date of Patent: April 11, 1989
    Assignee: Aktiebolaget Draco
    Inventors: Ralph L. Brattsand, Bror A. Thalen
  • Patent number: 4804656
    Abstract: The invention refers to compounds having anti-inflammatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula X.sub.1 represents a hydrogen, chlorine, bromine or fluorine atom;X.sub.2 represents a hydrogen, chlorine, bromine or fluorine atom;R.sub.1 represents a .beta.-hydroxy group, a .beta.-chlorine atom or an oxo group;R.sub.2 represents a hydrogen atom, a methylene group or an .alpha.- or .beta.-methyl group;R.sub.3 represents a hydrogen atom or an acyl group of 1 through 8 carbon atoms;R.sub.4 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group;R.sub.5 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group;Y represents either CR.sub.7 R.sub.8, O, S or NR.sub.9, where R.sub.7, R.sub.8 and R.sub.9 are selected from hydrogen or from straight or branched hydrocarbon chains having 1-8 carbon atoms or from a phenyl group.R.sub.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: February 14, 1989
    Assignee: Aktiebolaget Draco
    Inventors: Paul H. Andersson, Per T. Andersson, Bengt I. Axelsson, Bror A. Thalen, Jan W. Trofast
  • Patent number: 4404200
    Abstract: The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in position 22, in which formula A is n-propyl or n-butyl and Z is hydroxyl or hydroxyl esterified with a fatty acid with a straight or branched hydrocarbon chain having 1-5 carbon atoms.The invention also refers to a process for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment and control of inflammatory conditions.
    Type: Grant
    Filed: November 17, 1981
    Date of Patent: September 13, 1983
    Assignee: Aktiebolaget Draco
    Inventors: Bror A. Thalen, Ralph L. Brattsand