Abstract: A nucleic acid molecule which interacts with reverse transcriptase of a retrovirus. The nucleic acid molecule comprises a nucleotide sequence essentially composed of two stem-loop structures and a short bridge between the stems, which molecule for the purposes of the interaction with reverse transcriptase is analogous to the dihydrouridine (D)-stem-loop and anti-codon (A)-stem-loop of a mammalian transfer RNA (tRNA). Optionally, in the nucleic acid molecule, some or all of the normal phosphodiester nucleoside linkages have been substituted with phosphorothioate linkages. The invention further relates to the use of said nucleic acid molecule for the manufacture of a medicament for the inhibition of the interaction of HIV-1 and HIV-2 reverse transcriptase with tRNALys3.