Patents by Inventor Bruce A. Beutel

Bruce A. Beutel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Patent number: 8748627
    Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 10, 2014
    Assignee: AbbVie Inc.
    Inventors: Yu Gui Gu, Moshe Weitzberg, Xiangdong Xu, Richard F. Clark, Tianyuan Zhang, Qun Li, Todd M. Hansen, Hing Sham, Bruce A. Beutel, Heidi S. Camp, Xiaojun Wang
  • Antibacterial compounds
    Patent number: 7737159
    Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 15, 2010
    Assignee: Abbott Laboratories
    Inventors: David D. Anderson, Bruce A. Beutel, Curt S. Cooper, Yu-Gui Gu, Mira M. Hinman, Douglas M. Kalvin, Robert F. Keyes, Xenia B. Searle, Rolf Wagner
  • Antibacterial compounds
    Patent number: 7196200
    Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: March 27, 2007
    Assignee: Abbott Laboratories
    Inventors: David D. Anderson, Bruce A. Beutel, Curt S. Cooper, Yu-Gui Gu, Mira M. Hinman, Douglas M. Kalvin, Robert F. Keyes, Xenia B. Searle, Rolf Wagner
  • Method for the structural determination of ligands bound to macromolecular targets by nuclear magnetic resonance
    Publication number: 20040038216
    Abstract: The present invention pertains to a method for determining the three-dimensional structure of a macromolecule in complex with a ligand for the design of new pharmaceutically active compounds and other chemical entities.
    Type: Application
    Filed: August 23, 2002
    Publication date: February 26, 2004
    Inventors: Philip J. Hajduk, Bruce A. Beutel, Peter J. Dandliker
  • Continuous format high throughput screening
    Patent number: 5976813
    Abstract: Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range of biological or biochemical activity. In addition, CF-HTS is useful to perform multi-step assays.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: November 2, 1999
    Assignee: Abbott Laboratories
    Inventors: Bruce A. Beutel, Mark E. Schurdak, Martin J. Voorbach, David J. Burns, Mary K. Joseph
  • Determination and identification of active compounds in a compound library
    Patent number: 5866334
    Abstract: Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined by a reiterative process in which a change in the rate of recovery (elimination) of compounds that bind to the target indicates that the library contains such a compound. The procedure may also be used to determine indirectly the sequence of such compound by employing sublibraries, each of which have a known entity at a known position of the compound.
    Type: Grant
    Filed: July 16, 1996
    Date of Patent: February 2, 1999
    Assignee: Genzyme Corporation
    Inventor: Bruce A. Beutel
  • Reiterative method for screening combinatorial libraries
    Patent number: 5670326
    Abstract: Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined by a reiterative process in which a change in the rate of recovery (elimination) of compounds that bind to the target indicates that the library contains such a compound. The procedure may also be used to determine indirectly the sequence of such compound by employing sublibraries, each of which have a known entity at a known position of the compound.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: PharmaGenics, Inc.
    Inventor: Bruce A. Beutel
  • Inhibition of interferon-.gamma. with oligonucleotides
    Patent number: 5599917
    Abstract: Oligonucleotides and analogs thereof that bind to and preferably modulate the activity of interferon-.gamma., and methods for their use, including therapeutic and diagnostic methods are disclosed.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: February 4, 1997
    Assignee: PharmaGenics, Inc.
    Inventors: George R. Coppola, Bruce A. Beutel, Arthur H. Bertelsen