Patents by Inventor Bruce A. Buckingham
Bruce A. Buckingham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220125886Abstract: Compositions and methods for treating diabetes are disclosed. In particular, the invention relates to co-formulations of amylin analogues with insulin analogues for treatment of diabetes.Type: ApplicationFiled: February 12, 2020Publication date: April 28, 2022Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric A. APPEL, Bruce A. BUCKINGHAM, David M. MAAHS, Caitlin MAIKAWA, Gillie Agmon ROTH
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Patent number: 9227014Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: GrantFiled: February 7, 2014Date of Patent: January 5, 2016Assignees: The Board of Trustees of the Laland Stanford Junior University, The Regents of the University of California, a California Corporation, The Regents of the University of Colorado, a body corporate, Rensselaer Polytechnic InstituteInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
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Publication number: 20140221966Abstract: Techniques for controlling an insulin pump include determining values for parameters selected from a group including a first prediction time horizon, a predicted glucose threshold (Goff) for turning the insulin pump off, a maximum shut off time within a time window, and duration of the time window. A safety rule is determined based on the maximum shut off time within the duration. Glucose readings are collected up to a current time. An expected current glucose value G and glucose temporal rate of change are determined based only on the glucose readings and a Kalman filter configured for noisy glucose readings. A glucose level (Gh1) is predicted for a future time that is the prediction time horizon after the current time. A command is issued to shut off the insulin pump if it is determined both that Gh1 is less than Goff and that the safety rule is satisfied.Type: ApplicationFiled: February 7, 2014Publication date: August 7, 2014Applicants: The Board of Trustees of the Leland Stanford Junior University, Rensselaer Polytechnic Institute, The Regents of the University of Colorado, a body corporate, The Regents of the University of California, a California CorporationInventors: Bruce A. Buckingham, B. Wayne Bequette, Fraser Cameron, Darrell M. Wilson, H. Peter Chase, Francis J. Doyle, III, Matthew Stenerson
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Publication number: 20100174228Abstract: A system for predicting hypoglycemia based on continuous blood glucose monitor values is provided. The hypoglycemia detection algorithm is a set of individual alarms that are combined through a voting system into one combined alarm. The system could have five components and an overall voting algorithm that produces a binary alarm outcome depending on the number of constituent algorithms that report an alarm. A controller system automatically shuts off the insulin pump when pending or real hypoglycemia has been reached. The algorithms operate in a closed loop and automatically take action when the subject is asleep.Type: ApplicationFiled: October 26, 2009Publication date: July 8, 2010Inventors: Bruce Buckingham, Günter Niemeyer, Darrell M. Wilson, Fraser Cameron, H. Peter Chase, Eyal Dassau, Hyunjin Lee, B. Wayne Bequette, Francis J. Doyle, III
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Publication number: 20030195404Abstract: A real-time controller operating as an artificial pancreas uses a Kalman control algorithm to control glucose level of a patient in real time. The real-time controller receives an estimate of the patient glucose level and a reference glucose level. The estimate of the patient glucose level can be provided by an optimal estimator implemented using a linearized Kalman filter. The estimated glucose level and the reference glucose level are processed by the Kalman control algorithm to determine a control command in real time. The Kalman control algorithm has a dynamic process forced by the control command a cost function determining a relative level of control. The control command is provided to a dispenser which secretes insulin or glucagon in response to the control command to correct a relatively high glucose level or a relatively low glucose level.Type: ApplicationFiled: April 16, 2003Publication date: October 16, 2003Inventors: Edward J. Knobbe, Wah L. Lim, Bruce A. Buckingham
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Patent number: 6575905Abstract: A real-time glucose estimator uses a linearized Kalman filter to determine a best estimate of glucose level in real time. The real-time glucose estimator receives at least one measurement corresponding to glucose level. The measurement can be obtained with one or more sensors and is provided to the linearized Kalman filter in real time. The linearized Kalman filter has dynamic models and executes a recursive routine to determine the best estimate of glucose level based upon the measurement. Additional information can be provided to the linearized Kalman filter for initialization, configuration, and the like. Outputs of the linearized Kalman filter can be provided to a patient health monitor for display or for statistical testing to determine status of the real-time glucose estimator. The real-time glucose estimator can be implemented using a software algorithm.Type: GrantFiled: September 21, 2001Date of Patent: June 10, 2003Assignee: Knobbe, Lim & BuckinghamInventors: Edward J. Knobbe, Wah L. Lim, Bruce A. Buckingham
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Patent number: 6572545Abstract: A real-time controller operating as an artificial pancreas uses a Kalman control algorithm to control glucose level of a patient in real time. The real-time controller receives an estimate of the patient glucose level and a reference glucose level. The estimate of the patient glucose level can be provided by an optimal estimator implemented using a linearized Kalman filter. The estimated glucose level and the reference glucose level are processed by the Kalman control algorithm to determine a control command in real time. The Kalman control algorithm has a dynamic process forced by the control command a cost function determining a relative level of control. The control command is provided to a dispenser which secretes insulin or glucagon in response to the control command to correct a relatively high glucose level or a relatively low glucose level.Type: GrantFiled: September 21, 2001Date of Patent: June 3, 2003Assignee: Knobbe, Lim & BuckinghamInventors: Edward J. Knobbe, Wah L. Lim, Bruce A. Buckingham
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Publication number: 20020111547Abstract: A real-time controller operating as an artificial pancreas uses a Kalman control algorithm to control glucose level of a patient in real time. The real-time controller receives an estimate of the patient glucose level and a reference glucose level. The estimate of the patient glucose level can be provided by an optimal estimator implemented using a linearized Kalman filter. The estimated glucose level and the reference glucose level are processed by the Kalman control algorithm to determine a control command in real time. The Kalman control algorithm has a dynamic process forced by the control command a cost function determining a relative level of control. The control command is provided to a dispenser which secretes insulin or glucagon in response to the control command to correct a relatively high glucose level or a relatively low glucose level.Type: ApplicationFiled: September 21, 2001Publication date: August 15, 2002Inventors: Edward J. Knobbe, Wah L. Lim, Bruce A. Buckingham
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Publication number: 20020099282Abstract: A real-time glucose estimator uses a linearized Kalman filter to determine a best estimate of glucose level in real time. The real-time glucose estimator receives at least one measurement corresponding to glucose level. The measurement can be obtained with one or more sensors and is provided to the linearized Kalman filter in real time. The linearized Kalman filter has dynamic models and executes a recursive routine to determine the best estimate of glucose level based upon the measurement. Additional information can be provided to the linearized Kalman filter for initialization, configuration, and the like. Outputs of the linearized Kalman filter can be provided to a patient health monitor for display or for statistical testing to determine status of the real-time glucose estimator. The real-time glucose estimator can be implemented using a software algorithm.Type: ApplicationFiled: September 21, 2001Publication date: July 25, 2002Inventors: Edward J. Knobbe, Wah L. Lim, Bruce A. Buckingham