Patents by Inventor Bruce A. Ellsworth

Bruce A. Ellsworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GALECTIN-3 INHIBITORS
    Publication number: 20230303538
    Abstract: The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
    Type: Application
    Filed: May 27, 2021
    Publication date: September 28, 2023
    Inventors: CHUNJIAN LIU, Wei Wang, Bruce A. Ellsworth, James Aaron Balog, Alicia Regueiro-Ren
  • SMALL MOLECULE INHIBITORS OF GALECTIN-3
    Publication number: 20220185800
    Abstract: The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 16, 2022
    Inventors: Chunjian Liu, David S. Yoon, Wei Wang, Jianxin Feng, Bruce A. Ellsworth, Alicia Regueiro-Ren
  • SMALL MOLECULE INHIBITORS OF GALECTIN-3
    Publication number: 20220144818
    Abstract: The present disclosure relates to compounds of Formula (I) or (II), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
    Type: Application
    Filed: April 8, 2020
    Publication date: May 12, 2022
    Inventors: Chunjian Liu, Jianxin Feng, Pratik Devasthale, Natesan Murugesan, Bruce A. Ellsworth, Alicia Regueiro-Ren, Susheel Jethanand Nara, Prasada Rao Jalagam, Manoranjan Panda
  • Pyrrolidine GPR40 modulators
    Patent number: 10301260
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: May 28, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiang-Yang Ye, Bruce A. Ellsworth, Elizabeth A. Jurica
  • Pyrrolidine GPR40 modulators
    Patent number: 9714231
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: July 25, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce A. Ellsworth, Elizabeth A. Jurica, Jun Shi, William R. Ewing, Xiang-Yang Ye, Ximao Wu, Zhu Yeheng, Sun Chongqing
  • Dihydropyrazole GPR40 modulators
    Patent number: 9656963
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: May 23, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andres S. Hernandez, Bruce A. Ellsworth, William R. Ewing, Bin Chen
  • Dihydropyrazole GPR40 modulators
    Patent number: 9604964
    Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: March 28, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce A. Ellsworth, Jun Shi, William R. Ewing, Elizabeth A. Jurica, Andres S. Hernandez, Ximao Wu, Zhengxiang Gu, Zhenqiu Hong, Stephen P. O'Connor
  • PYRROLIDINE GPR40 MODULATORS
    Publication number: 20170081282
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 23, 2017
    Inventors: Xiang-Yang Ye, Bruce A. Ellsworth, Elizabeth A. Jurica
  • DIHYDROPYRAZOLE GPR40 MODULATORS
    Publication number: 20160297797
    Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 13, 2016
    Inventors: Bruce A. Ellsworth, Jun Shi, William R. Ewing, Elizabeth A. Jurica, Andres S. Hernandez, Ximao Wu, Zhengxiang Gu, Zhenqiu Hong, Stephen P. O'Connor
  • PYRROLIDINE GPR40 MODULATORS
    Publication number: 20160280680
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: November 15, 2013
    Publication date: September 29, 2016
    Inventors: Bruce A. Ellsworth, Elizabeth A. Jurica, Jun Shi, William R. Ewing, Xiang-Yang Ye, Ximao Wu, Zhu Yeheng, Sun Chongqing
  • DIHYDROPYRAZOLE GPR40 MODULATORS
    Publication number: 20160280659
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: November 15, 2013
    Publication date: September 29, 2016
    Inventors: Andres S. Hernandez, Bruce A. Ellsworth, William R. Ewing, Bin Chen
  • Dihydropyrazole GPR40 modulators
    Patent number: 9133163
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: September 15, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce A. Ellsworth, Jun Shi, William R. Ewing, Elizabeth A. Jurica, Andres S. Hernandez, Ximao Wu
  • METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS
    Publication number: 20140243517
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: AstraZeneca AB
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • DIHYDROPYRAZOLE GPR40 MODULATORS
    Publication number: 20140142139
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 22, 2014
    Inventors: Bruce A. Ellsworth, Jun Shi, William R. Ewing, Elizabeth A. Jurica, Andres S. Hernandez, Ximao Wu
  • Pyrrolidine GPR40 modulators
    Patent number: 8288404
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: October 16, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bruce A. Ellsworth, William R. Ewing, Elizabeth Jurica
  • Tetrahydroquinoline derivatives as cannabinoid receptor modulators
    Patent number: 8119808
    Abstract: The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic disorders, obesity, cognitive disorders, neurological disorders, pain disorders, inflammation disorders, in the promotion of smoking cessation and for the treatment of other psychiatric disorders Also provided are pharmaceutical compositions containing such compounds and pharmaceutical combinations of the compounds of the invention with other therapeutic agents.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: February 21, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chongqing Sun, Doree Sitkoff, William R. Ewing, Yanting Huang, Bruce A. Ellsworth, Richard B. Sulsky, Annapurna Pendri, Samuel Gerritz, Natesan Murugesan, Zhengxiang Gu
  • Methods of Producing C-Aryl Glucoside SGLT2 Inhibitors
    Publication number: 20110201795
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • Indole indane amide compounds useful as CB2 agonists and method
    Patent number: 7943658
    Abstract: Indole indane amides which are CB2 agonists are provided which have the structure wherein R1, R2, R3, R4 and R5 are as defined herein, which compounds are useful in treating autoimmune diseases, inflammation, pain, cardiovascular disorders and other diseases mediated by CB2 receptors. A method for preventing or treating such diseases employing the compounds of the invention is also provided.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: May 17, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chunjian Liu, Stephen T. Wrobleski, Katerina Leftheris, Gang Wu, Philip M. Sher, Bruce A. Ellsworth
  • TETRAHYDROQUINOLINE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
    Publication number: 20110104315
    Abstract: The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic disorders, obesity, cognitive disorders, neurological disorders, pain disorders, inflammation disorders, in the promotion of smoking cessation and for the treatment of other psychiatric disorders Also provided are pharmaceutical compositions containing such compounds and pharmaceutical combinations of the compounds of the invention with other therapeutic agents.
    Type: Application
    Filed: January 5, 2011
    Publication date: May 5, 2011
    Inventors: Chongqing Sun, Doree Sitkoff, William R. Ewing, Yanting Huang, Bruce A. Ellsworth, Richard B. Sulsky, Annapurna Pendri, Samuel Gerritz, Natesan Murugesan, Zhengxiang Gu
  • Methods of producing C-aryl glucoside SGLT2 inhibitors
    Patent number: 7932379
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: April 26, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas