Patents by Inventor Bruce A. Given

Bruce A. Given has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE REDUCTION OF Z-AAT PROTEIN LEVELS
    Publication number: 20230348905
    Abstract: Described are methods of reducing liver Z-AAT protein levels in a human subject with a PiZZ genotype of alpha-1 antitrypsin (AAT) by using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human subject with a PiZZ mutation, lead to a reduction in liver Z-AAT protein levels, including both soluble and insoluble Z-AAT protein. Such reductions can lead to the treatment of liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.
    Type: Application
    Filed: September 14, 2021
    Publication date: November 2, 2023
    Applicant: Arrowhead Pharmaceuticals, Inc.
    Inventors: Dawn Christianson, James C. Hamilton, Bruce Given
  • METHODS FOR THE TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD)
    Publication number: 20220305046
    Abstract: Described are methods for treating alpha-1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 29, 2022
    Applicant: Arrowhead Pharmaceuticals, Inc.
    Inventors: Bruce Given, Dawn Christianson, James C. Hamilton, Zhen Li, Rui Zhu, Christine Wooddell, Tao Pei
  • Methods and compositions for treatment of sleep apnea
    Publication number: 20080085313
    Abstract: Provided herein are methods of treatment of sleep apnea by administering an endothelin antagonist, such as sitaxsentan or a pharmaceutically acceptable salt thereof to a patient in need of the treatment.
    Type: Application
    Filed: May 15, 2007
    Publication date: April 10, 2008
    Inventors: Bruce Given, Richard Dixon
  • Methods and compositions for treatment of diastolic heart failure
    Publication number: 20070232671
    Abstract: Provided herein are methods of treatment of diastolic heart failure (DHF) by administering an endothelin antagonist, such as sitaxsentan or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 12, 2007
    Publication date: October 4, 2007
    Inventors: Bruce Given, Richard Dixon
  • Ceramic aluminum laminate and thermally conductive adhesive therefor
    Patent number: 5490895
    Abstract: A 51/2" by 53/4" flat ceramic board is bonded to an aluminum frame which serves as a heat sink. The bonding agent intermediate the board and the frame is thermally conductive and comprises an epoxy containing Master Bond EP21TDCAOHT. The formed laminate or bond is capable of withstanding repeated stresses occurring through thermal cycling in temperatures from -60 degrees centigrade to +125 degrees centigrade and vibration and humidity testing.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: February 13, 1996
    Assignee: TRW Inc.
    Inventors: Mansheng Wang, Bruce A. Given
  • Ceramic aluminum laminate and thermally conductive adhesive therefor
    Patent number: 5180625
    Abstract: A 51/2" by 53/4" flat ceramic board is bonded to an aluminum frame which serves as a heat sink. The bonding agent intermediate the board and the frame is thermally conductive and comprises an epoxy containing Master Bond EP21TDCAOHT. The formed laminate or bond is capable of withstanding repeated stresses occurring through thermal cycling in temperatures from -60 degrees centigrade to +125 degrees centigrade and vibration and humidity testing.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: January 19, 1993
    Assignee: TRW Inc.
    Inventors: Mansheng Wang, Bruce A. Given