Patents by Inventor Bruce A. Green
Bruce A. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060051387Abstract: A two-part sterilant system comprises a first part comprising a first reagent in a carrier medium and a second part which is miscible with the first part and which comprises a second reagent in a carrier medium. The first reagent and the second reagent will react when mixed to provide a sterilising composition. The first part is contained in a pump dispenser (2) whereby it may be dispensed as a fluid, and the second part is absorbed or impregnated in at least one fabric member (18) in a sealed container (20).Type: ApplicationFiled: September 7, 2004Publication date: March 9, 2006Inventor: Bruce Green
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Publication number: 20060043416Abstract: A semiconductor structure includes a first semiconductor layer, a second semiconductor layer over the first semiconductor layer, a third semiconductor layer over the second semiconductor layer, and a fourth semiconductor layer over the third semiconductor layer. A first conductive portion is coupled to the first semiconductor layer, and a second conductive portion is formed over the first semiconductor layer.Type: ApplicationFiled: August 25, 2004Publication date: March 2, 2006Inventors: Hsin-Hua P. Li, Bruce Green, Olin Hartin, Ellen Lan, Charles Weitzel
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Publication number: 20050249746Abstract: A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.Type: ApplicationFiled: March 13, 2003Publication date: November 10, 2005Inventors: Bruce Green, Gary Zlotnick, Leah Fletcher, Arnold Smith, Thomas Reilly
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Publication number: 20050240627Abstract: An image server store having a combined image including a first image of a first software combined with other images of other software such that any one or more of the images can be restored from the combined image, and methods relating thereto. The method of making the combined image comprises creating a first image from a first software, creating a second image from the second software, and combining the first image and the second image into the combined image on the server store. Each image includes first descriptive data (metadata) corresponding to descriptive data of its software and includes file data corresponding to file data of its software.Type: ApplicationFiled: June 17, 2005Publication date: October 27, 2005Applicant: Microsoft CorporationInventors: Jason Cohen, Ryan Burkhardt, Bruce Green
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Publication number: 20050104087Abstract: In one embodiment, a semiconductor device (500) includes a buffer layer (504) formed over a substrate (502). An AlxGa1-xAs layer (506) is formed over the buffer layer (504) and has a first doped region (508) formed therein. An InxGa1-xAs channel layer (512) is formed over the AlxGa1-xAs layer (506). An InxGa1-xP barrier layer (518) is formed over the InxGa1-xAs channel layer (512), the InxGa1-xP layer (518) has a second doped region formed therein. A control electrode (526) is formed over the InxGa1-xP layer (518). An undoped GaAs layer (520) is formed over the InxGa1-xP layer (518) adjacent to the control electrode (526). A doped GaAs layer (524) is formed over the undoped GaAs layer (520) and on opposite sides of the control electrode (526) and provides first and second current electrodes. When used to amplify a digital modulation signal, the semiconductor device (500) maintains linear operation over a wide temperature range.Type: ApplicationFiled: June 30, 2004Publication date: May 19, 2005Inventors: Ellen Lan, Monica De Baca, Bruce Green, Monte Miller, Charles Weitzel
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Publication number: 20040181036Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 4, 2003Publication date: September 16, 2004Inventors: Bruce A Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20040176571Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 4, 2003Publication date: September 9, 2004Applicant: Wyeth Holdings CorporationInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20040052816Abstract: The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus Pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to reduce colonization of pneumococcal bacteria. Thus the present invention also pertains to compositions for the treatment and prophylaxis of infection or inflammation associated with bacterial infection.Type: ApplicationFiled: May 29, 2003Publication date: March 18, 2004Inventors: Bruce A. Green, Amy W. Masi
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Patent number: 6420134Abstract: Protein “e” of H. influenzae, a lipoprotein of approximately 28,000 daltons, has been purified and sequenced. Protein “e” and peptides or proteins having a shared epitope, can be used to vaccinate against non-typable (and typable) H. influenzae and to prevent otitis media caused by H. influenzae. For this purpose, protein “e” or derivatives thereof can be produced in native, synthetic or recombinant forms and can be administered alone or in conjunction with other antigens of H. influenzae. Protein “e” can also be used in multivalent vaccines designed for H. influenzae and one or more other infectious organisms.Type: GrantFiled: May 23, 1995Date of Patent: July 16, 2002Assignee: Praxis Biologics, Inc.Inventors: Bruce A. Green, Gary W. Zlotnick
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Patent number: 5968769Abstract: The invention relates to the isolation and cloning of the structural gene, hipP, for the NTHi pili serotype 5 and the LKP operon. The invention relates to DNA molecules capable of hybridizing to the DNA sequences of the Haemophilus influenzae genome related to the pili. The invention further relates to a DNA molecule which encodes a pili protein, particularly a tip adhesion protein. The DNA molecules of the invention can be used in a method for assaying a sample, such as a blood sample, for the presence of Haemophilus influenzae in the sample. Accordingly, the invention further relates to the use of the DNA molecules as a diagnostic. The invention also relates to a recombinant Haemophilus influenzae pili protein, such as a tip adhesion protein. The protein can be employed in a method for immunizing an animal, such as a human, as a therapeutic or diagnostic.Type: GrantFiled: June 7, 1995Date of Patent: October 19, 1999Assignee: American Cyanamid Co. and Bactex, Inc.Inventors: Bruce A. Green, Charles C. Brinton, Jr.
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Patent number: 5955580Abstract: Protein "e" of H. influenzae, a lipoprotein of approximately 28,000 daltons, has been purified and sequenced. Protein "e" and peptides or proteins having a shared epitope, can be used to vaccinate against nontypable (and typable) H. influenzae and to prevent otitis media caused by H. influenzae. For this purpose, protein "e" or derivatives thereof can be produced in native, synthetic or recombinant forms and can be administered alone or in conjunction with other antigens of H. influenzae. Protein "e" can also be used in multivalent vaccines designed for H. influenzae and one or more other infectious organisms.Type: GrantFiled: May 23, 1995Date of Patent: September 21, 1999Assignee: Praxis Biologies, Inc.Inventors: Bruce A. Green, Gary W. Zlotnick
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Patent number: 5834187Abstract: The invention relates to the isolation and cloning of the structural gene, hipP, for the NTHi pili serotype 5 and the LKP operon. The invention relates to DNA molecules capable of hybridizing to the DNA sequences of the Haemophilus influenzae genome related to the pili. The invention further relates to a DNA molecule which encodes a pili protein, particularly a tip adhesion protein. The DNA molecules of the invention can be used in a method for assaying a sample, such as a blood sample, for the presence of Haemophilus influenzae in the sample. Accordingly, the invention further relates to the use of the DNA molecules as a diagnostic. The invention also relates to a recombinant Haemophilus influenzae pili protein, such as a tip adhesion protein. The protein can be employed in a method for immunizing an animal, such as a human, as a therapeutic or diagnostic.Type: GrantFiled: June 7, 1995Date of Patent: November 10, 1998Assignee: Bactex, Inc.Inventors: Bruce A. Green, Charles C. Brinton, Jr.
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Patent number: 5780601Abstract: "A method of purifying protein "e" from Haemophilus influenzae includes disrupting H. influenzae cells, subjecting the disrupted cells by differential sedimentation to obtain a total cell membrane fraction, fractionating the total cell membrane into inner and outer membrane components by density gradient sedimentation or by differential solubilization of the inner membrane component with detergents, obtaining a subfraction of the preparation of the outer membrane components which is enriched in protein "e" by extraction with an aqueous solution of 0.1-2.0% N-lauroyl sarcosine, sodium salt, solubilizing the protein "e" from the subfraction by a two-step differential solubilization process with sulfobetaine detergents, and recovering the aqueous solution which contains the purified protein "e".Type: GrantFiled: May 23, 1995Date of Patent: July 14, 1998Assignee: Praxis Biologics, Inc.Inventors: Bruce A. Green, Gary W. Zlotnick
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Patent number: 5643725Abstract: The isolation and cloning of the structural gene, hifA, for the NTHi pili serotype 5 and the serotype 1 LKP operon, DNA molecules capable of hybridizing to the DNA sequences of the Haemophilus influenzae genome related to the serotype 1 LKP operon and DNA molecules which encode LKP proteins are described.Type: GrantFiled: July 19, 1994Date of Patent: July 1, 1997Assignees: American Cyanamid Company, Bactex, Inc.Inventors: Bruce A. Green, Charles C. Brinton, Jr.
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Patent number: 5601831Abstract: Protein "e" of H. influenzae, a lipoprotein of approximately 28,000 daltons, has been purified and sequenced. Protein "e" and peptides or proteins having a shared epitope, can be used to vaccinate against non-typable (and typable) H. influenzae and to prevent otitis media caused by H. influenzae. For this purpose, protein "e" or derivatives thereof can be produced in native, synthetic or recombinant forms and can be administered alone or in conjunction with other antigens of H. influenzae. Protein "e" can also be used in multivalent vaccines designed for H. influenzae and one or more other infectious organisms.Type: GrantFiled: March 9, 1990Date of Patent: February 11, 1997Assignee: Praxis Biologics, Inc.Inventors: Bruce A. Green, Gary W. Zlotnick
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Patent number: 5196338Abstract: Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections.Type: GrantFiled: February 15, 1990Date of Patent: March 23, 1993Assignee: Praxis Biologics, Inc.Inventors: Algis Anilionis, Robert C. Seid, Jr., Robert A. Deich, Gary W. Zlotnick, Bruce A. Green
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Patent number: 5110908Abstract: Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of puiification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization.Type: GrantFiled: November 9, 1989Date of Patent: May 5, 1992Assignee: Praxis Biologics, Inc.Inventors: Robert A. Deich, Gary Zlotnick, Bruce Green
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Patent number: 5108744Abstract: Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods includng novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequence encoding PBOMP-1 and PBOMP-2 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization.Type: GrantFiled: November 9, 1989Date of Patent: April 28, 1992Assignee: Praxis Biologics, Inc.Inventors: Robert A. Deich, Gary W. Zlotnick, Bruce A. Green
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Patent number: 5098997Abstract: Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections.Type: GrantFiled: September 1, 1988Date of Patent: March 24, 1992Assignee: Praxis Biologics, Inc.Inventors: Algis Anilionis, Robert C. Seid, Jr., Robert A. Deich, Gary W. Zlotnick, Bruce A. Green
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Patent number: 3965334Abstract: A heating device, comprising a tubular body whose inner wall bounds a heating chamber for objects. Between the inner wall and the outer wall of this body a plurality of ducts is provided which are situated in a ring-shape about the heating chamber and which extend parallel to the tube axis. These ducts are separated from each other by rigid partitions. Each duct contains evaporable heat transport medium.Type: GrantFiled: April 25, 1973Date of Patent: June 22, 1976Inventors: George Albert Apolonia Asselman, David Bruce Green, Adrianus Petrus Johannes Castelijns, Pieter Aart Naastepad, Jacob Willem De Ruiter