Patents by Inventor Bruce A. Hay

Bruce A. Hay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210163418
    Abstract: Formulated and/or co-formulated liposomes comprising IDO prodrugs and methods of making the liposomes are disclosed herein. The IDO prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit IDO-1. The IDO prodrugs can be formulated and/or co-formulated into a liposome to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.
    Type: Application
    Filed: November 12, 2020
    Publication date: June 3, 2021
    Inventors: David Stover, Dhruba Bharali, Bruce A Hay, Tahmineh Safaie
  • Patent number: 10966414
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: April 6, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Patent number: 10961204
    Abstract: Chemical compounds/compositions, methods of synthesis, and methods of use. The compounds/compositions are directed toward thyrointegrin antagonists conjugated to a polymer. The compounds/compositions further comprise an additional substituent also conjugated to the polymer. The compounds/compositions demonstrate increased uptake across the blood brain barrier along with increased retention therein and retention within tumor. The compounds/compositions may also include improved synthesis scalability, improved purity, improved aqueous solubility, and a solid product or intermediate. The compounds/compositions may demonstrate improved antiangiogenic effect and improved efficacy against conditions, particularly cancers, requiring blood brain barrier permeability, for example, glioblastoma (GBM).
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: March 30, 2021
    Assignee: NANOPHARMACEUTICALS LLC
    Inventors: Shaker A. Mousa, Bruce A. Hay
  • Publication number: 20200404892
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Application
    Filed: August 27, 2020
    Publication date: December 31, 2020
    Inventors: Bruce A Hay, Omar S. Akbari, Anna B. Buchman
  • Patent number: 10791722
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: October 6, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20200140885
    Abstract: Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.
    Type: Application
    Filed: November 4, 2019
    Publication date: May 7, 2020
    Inventors: Bruce A. Hay, Georg Oberhofer, Tobin William Ivy
  • Patent number: 10570200
    Abstract: The present disclosure generally relates to methods and compositions for contraception. In some embodiments, vector based approaches for contraception are provided.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 25, 2020
    Assignee: California Institute of Technology
    Inventors: Bruce A. Hay, Juan Li
  • Publication number: 20180320164
    Abstract: Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.
    Type: Application
    Filed: May 3, 2018
    Publication date: November 8, 2018
    Inventors: Bruce A Hay, Georg Oberhofer, Tobin William Ivy
  • Publication number: 20160345556
    Abstract: Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
    Type: Application
    Filed: May 25, 2016
    Publication date: December 1, 2016
    Inventors: Bruce A. Hay, Omar S. Akbari, Anna B. Buchman
  • Publication number: 20160060358
    Abstract: Described are compositions and methods for the induction of an antigen-specific tolerance in a vertebrate. Also described are compositions and methods for the induction of antigen-specific tolerance using a fusion or a complex of the antigen (e.g., an antibody or an enzyme) against which tolerance is desired with a phosphatidylserine-binding domain derived from a phosphatidylserine-binding protein (including peptides).
    Type: Application
    Filed: August 27, 2015
    Publication date: March 3, 2016
    Inventor: Bruce A. Hay
  • Publication number: 20150237838
    Abstract: The present technology generally relates to compositions, methods, and populations that allow for the regulation of insect population.
    Type: Application
    Filed: February 25, 2015
    Publication date: August 27, 2015
    Inventors: BRUCE A. HAY, OMAR S. AKBARI
  • Publication number: 20140283155
    Abstract: Disclosed herein are components, systems and methods for regulating population of multicellular organisms, for example insects.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Inventors: Omar S. Akbari, Katie L. Kennedy, Bruce A. Hay
  • Publication number: 20140223591
    Abstract: The present disclosure generally relates to methods and compositions for contraception. In some embodiments, vector based approaches for contraception are provided.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 7, 2014
    Applicant: California Institute of Technology
    Inventors: Bruce A. Hay, Juan Li
  • Publication number: 20100292205
    Abstract: The invention pertains to pyrimidone compounds that serve as effective GSK-3 inhibitors. The invention further relates to pharmaceutical compositions and methods comprising such pyrimidone compounds; and the use of such compounds for treating certain disorders.
    Type: Application
    Filed: August 13, 2007
    Publication date: November 18, 2010
    Applicant: PFIZER INC.
    Inventors: Bruce A. Lefker, Michael A. Brodney, Subas M. Sakya, Bruce A. Hay, Matthew D. Wessel, Edward L. Conn
  • Publication number: 20060057069
    Abstract: Disclosed is a class of reagents for examining protein expression in vivo that does not require transfection, radiolabeling, or the prior choice of a candidate gene. Further, a series of puromycin conjugates was constructed bearing various labeling moieties. These conjugates were readily incorporated into expressed protein products in cell lysates in vitro and efficiently cross cell membranes to function in protein synthesis in vivo as indicated by flow cytometry, selective enrichment studies, and western analysis. The present invention demonstrates that labeled-puromycin conjugates offer a general means to examine protein expression in vivo.
    Type: Application
    Filed: June 7, 2005
    Publication date: March 16, 2006
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Shelley Starck-Green, Harry Green, Jose Alberola-ila, Richard Roberts, Erin Schuman, William Smith, Bruce Hay
  • Publication number: 20050246717
    Abstract: A database system providing stored procedures as web services is described. In one embodiment, for example, in a database system, a method of the present invention is described for providing a stored procedure as a Web service, the method comprises steps of: predefining a stored procedure to be invoked upon receiving a client request for a particular Web service; receiving an incoming request from a particular client for the particular Web service; in response to the incoming request, identifying the stored procedure that is predefined for the particular Web service; executing the identified stored procedure for generating a result set; and returning the result set back to the particular client.
    Type: Application
    Filed: April 29, 2004
    Publication date: November 3, 2005
    Applicant: SYBASE, INC.
    Inventors: John Poole, Mark Culp, Graeme Perrow, Bruce Hay
  • Publication number: 20050054581
    Abstract: Compounds according formula (I) A-G-Z-W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, A is (C6-C10)aryl, (C6-C10)aryl-SO2, (C6-C10)aryl-CH2—, (C6-C10)arylcarbonyl, (C1-C9)heteroaryl, (C1-C9)heteroaryl-SO2—, (C1-C9)heteroaryl-CH2—; or (C1-C9)heteroarylcarbonyl; G is selected from the group consisting of: where B is (C6-C10)aryl or (C1-C9)heteroaryl, and X is CH2, SO2, or carbonyl; where X is CH2, SO2, or carbonyl; and R1 and R1? are each independently selected from H, CN, (C1-C8)alkyl-, and phenyl(CH2)—, wherein said alkyl and phenyl groups are optionally substituted; and where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.
    Type: Application
    Filed: November 16, 2001
    Publication date: March 10, 2005
    Inventors: Bruce Hay, Bridget Cole, Anthony Ricketts
  • Publication number: 20040157834
    Abstract: Compounds according to the formula A-Z-W as herein described, wherein A is selected from the groups consisting of: A′-(CH2)n—, A′-(CH2)nSO2—, and A′-(CH2)nCO—, where n is 0 to 4; and A═ is selected from
    Type: Application
    Filed: February 9, 2004
    Publication date: August 12, 2004
    Applicant: Pfizer Inc
    Inventors: Bruce A. Hay, Bridget M. Cole, Anthony P. Ricketts
  • Patent number: 6720330
    Abstract: Compounds according to the formula A—Z—W as herein described, wherein A is selected from the groups consisting of: A′—(CH2)n—, A′—(CH2)nSO2—, and A′—(CH2)nCO—, where n is 0 to 4; and A′ is selected from (a) (C6-C10)aryl-, or (b) (C1-C9)heteroaryl-; which groups may be optionally substituted; and pharmaceutically acceptable salts, solvates or hydrates thereof; pharmaceutical compositions thereof; and methods useful to facilitate secretion of growth hormone(GH) in mammals.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: April 13, 2004
    Assignee: Pfizer Inc.
    Inventors: Bruce A. Hay, Bridget M. Cole, Anthony P. Ricketts
  • Publication number: 20040058877
    Abstract: Compounds according to the formula: 1
    Type: Application
    Filed: September 8, 2003
    Publication date: March 25, 2004
    Applicant: Pfizer Inc
    Inventors: Bruce A. Hay, Anthony P. Ricketts, Bridget M. Cole