Abstract: The present invention is directed to methods for the treatment of adenocarcinomas that are characterized by the overexpression of a particular oncogene, Pim-1. The procedure involves administering a therapeutically effective amount of interleukin-10 that has been coupled to a carrier that increases its circulating plasma half-life.

Abstract: A thermo-optic system, which may be used for example in thermal imaging, includes an array of optical elements each having a thermally responsive optical property, the optical elements including signal elements and reference elements configured to provide (1) a common-mode response of the optical property to ambient temperature and (2) a differential-mode response of the optical property to a thermal signal appearing across the array of optical elements. The system also includes an optical readout subsystem configured to (1) illuminate the array of optical elements with optical energy at a readout wavelength corresponding to the optical property so as to generate a composite optical signal having common-mode and differential-mode signal components corresponding to the common-mode and differential-mode responses respectively of the signal and reference elements, and (2) filter the composite optical signal to generate a filtered optical signal being substantially the differential-mode image component.

Abstract: A thermo-optic system, which may be used for example in thermal imaging, includes an array of optical elements each having a thermally responsive optical property, the optical elements including signal elements and reference elements configured to provide (1) a common-mode response of the optical property to ambient temperature and (2) a differential-mode response of the optical property to a thermal signal appearing across the array of optical elements. The system also includes an optical readout subsystem configured to (1) illuminate the array of optical elements with optical energy at a readout wavelength corresponding to the optical property so as to generate a composite optical signal having common-mode and differential-mode signal components corresponding to the common-mode and differential-mode responses respectively of the signal and reference elements, and (2) filter the composite optical signal to generate a filtered optical signal being substantially the differential-mode image component.

Abstract: The present invention is directed to methods for the treatment of adenocarcinomas that are characterized by the overexpression of a particular oncogene, Pim-1. The procedure involves administering a therapeutically effective amount of interleukin-10 that has been coupled to a carrier that increases its circulating plasma half-life.

Abstract: A position sensor having a wavefront compensator, a detector array and a grating in a diffractive configuration, and which incorporates a second wavefront compensator and a second detector array in parallel with the first wavefront compensator and detector array, to provide a second optical channel for measurement of an additional degree of freedom (roll), the effects of which can then be removed from or utilized in the main measurement channel; and in which the relative effects of grating roll and grating displacement are different in this second channel when compared to the first sensing channel; and in one embodiment of which this differentiation is created by having different ratios of the grating period to the detector fringe period in the two channels.

Abstract: The disclosed optical detector array includes a plurality of photodetectors and is useful for monitoring a signal that includes a first periodic component and a second periodic component. The second periodic component is characterized by a period T. Each of the photodetectors in the array is characterized by a length and a width. The width of each photodetector is substantially equal to an integer multiple of T.

Abstract: A position encoder and a method for estimating absolute position using two or more diffractive grating tracks of differing periods to generate interference fringe patterns on a multi-track sensor. Detectors, corresponding to the diffractive grating tracks, detect the interference fringes. A first processing circuitry coupled to the detectors extract phase signals from the signals from the detectors. A second processing circuitry then estimates the cycle counts of the track signals based on the phase signals from the first processing circuitry. The absolute position is estimated by combining the cycle count, the fractional fringe value, and the grating period.

Abstract: An index structure and method are disclosed which employ, in addition to a main diffractive grating track of an encoder, a short diffractive grating track (the vernier or index track) having a different frequency than that of the main track. The phase of the index track is used to provide windows for the main track in a manner so that a preselected phase condition of the main track occurs in only one of the windows provided by the index track.

Abstract: Position of a diffusely scattering surface is detected by interfering backscattered light from respective input beams which illuminate a common spot. Through polarization of the input beams and appropriate filtering, backscattered light is isolated from specularly reflected light and interfered to form a fringe pattern on a detector. The position sensor has particular applicability as a push pin sensor in a hard disk servo system.

Abstract: An optical system and a method for separating overlapping spectra from a diffraction grating and an imaging spectrometer with increased free spectral range are disclosed. The light from a diffraction grating consists of multiple spectra overlapping each other and displaced along a spectral axis. The invention directs the light from the grating to a refractive element such, as a prism. The prism further disperses the light along the same spectral axis. The individual spectra are sufficiently displaced such that they no longer interfere with each other.

Abstract: A method and apparatus for phasing the apertures of a multiple-aperture imaging system is disclosed. An imaging system gathers light in either a scanning or a staring mode from a natural or real scene without artificial light sources. The spatial frequency of the image is sensed. The phase of the apertures is adjusted until the spectral power is maximized within a preselected spatial frequency band. When the spectral power is maximized, the apertures are optimally phased.

Abstract: A method of fabricating a controlled harmonic grating having both binary magnitude and phase transmissions in which specified harmonics are enhanced and/or suppressed. The summing of a number of binary pulse trains produces a controlled harmonic grating transmission function. The binary grating is readily fabricated by applying strips of light blocking material corresponding to the occurrence of a zero value of the transmission function, and by forming light-transmissive strips coincident with the portions of the transmission function having an absolute value of 1. Strips of phase retarding material are also deposited having a relative phase shift of pi radians.

Abstract: A wavefront sensor employs a novel DC shearing interferometer which produces four interferograms which are 90.degree. phase shifted with respect to each other. The incoming wavefront is replicated into two beams, a portion of each being reflected off of a beamsplitter and the remaining portion being transmitted therethrough, at first and second portions of the beamsplitter. After leaving the beamsplitter the transmitted and reflected beams are reflected back 180.degree. by a pair of retroreflectors, and directed at third and fourth portions of the beamsplitter. The retroreflectors are adjusted to produce four shearing interferograms and a quarter wave plate is positioned in the path of one of the beams to cause the four interferograms to have a 90.degree. phase shifted relationship with respect to each other.