Patents by Inventor Bruce A. Kerwin

Bruce A. Kerwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized compositions containing hemoglobin
    Patent number: 6242417
    Abstract: The present invention relates to a hemoglobin compositions stabilized against the formation of aggregates. The present invention further relates to methods of making such hemoglobin compositions.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: June 5, 2001
    Assignee: Somatogen, Inc.
    Inventors: Michael J. Gerber, Douglas L. Looker, Bruce A. Kerwin
  • Globins containing binding domains
    Patent number: 6218513
    Abstract: The present invention relates to globins containing non-naturally occurring binding domains, In particular, the present invention is directed toward a binding domain comprising the oligomerizing domain GCN4 and GCN4 derivatives. Thc present invention also relates to multimeric hemoglobins comprised of at least one globin containing at least one non-naturally occurring binding domain.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: April 17, 2001
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Spencer J. Anthony-Cahill, Janet K. Epp, Bruce A. Kerwin, Peter O. Olins, Antony J. Mathews
  • Method for control of functionality during cross-linking of hemoglobins
    Patent number: 6160098
    Abstract: The present invention relates to cross-linked hemoglobins, and particularly to methods of controlling the functionality of such hemoglobins. The controlled functionalities include the P.sub.50 and the Hill coefficient. The present invention provides methods for producing a cross-linked hemoglobin with specific final functionalities by regulating the amount of both total hemoglobin and R-state hemoglobin prior to cross-linking, and by modulating cross-linking reaction conditions such as time, temperature, pH and the ratio of cross-linking reagent to hemoglobin.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: December 12, 2000
    Assignee: Baxter Biotech Technology Sarl
    Inventor: Bruce A. Kerwin
  • Modified hemoglobin-like compounds and methods of purifying same
    Patent number: 6150506
    Abstract: The present invention relates to modified hemoglobin-like polypeptides containing multiple dialpha (or dibeta) domains. The present invention also relates to multimeric hemoglobin-like proteins comprising covalently joined hemoglobin-like moieties. Another aspect of the inention is directed at a purification method of hemoglobin-like polypeptides utilizing ion exchange chromatography.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: November 21, 2000
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Stephen P. Trimble, Antony J. Mathews, Bruce A. Kerwin, David A. Marquardt, Spencer Anthony-Cahill, Janet K. Epp, Dominic G. Madril, David C. Anderson
  • Storage stable hemoglobin solutions
    Patent number: 5929031
    Abstract: The present invention relates to storage stable hemoglobin solutions which contain partially deoxygenated and surprisingly low amounts of reducing agents. Methods for preparing such storage stable hemoglobin solutions are also provided as well as a systems for storing the solutions.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: July 27, 1999
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Bruce A. Kerwin, Douglas L. Looker
  • Stabilized compositions containing hemoglobin
    Patent number: 5914391
    Abstract: The present invention relates to hemoglobin compositions stabilized against the formation of aggregates. Such compositions contain at least a surfactant, said surfactant not being an adduct of a polymer and an anionic ligand. The present invention further relates to methods of making such hemoglobin compositions.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: June 22, 1999
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Michael J. Gerber, Douglas L. Looker, Bruce A. Kerwin