Patents by Inventor Bruce A. Mosley

Bruce A. Mosley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-4 receptors
    Publication number: 20090226472
    Abstract: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
    Type: Application
    Filed: November 20, 2007
    Publication date: September 10, 2009
    Inventors: Bruce A. Mosley, David J. Cosman, Linda S. Park, M. Patricia Beckmann, Carl J. March, Rejean Idzerda
  • Rank-ligand-induced sodium/proton antiporter polypeptides
    Publication number: 20080200389
    Abstract: This invention relates to RIPPA, a new member of the human Na+/H+ antiporter polypeptide family, methods of making such polypeptides, and to methods of using RIPPA and RIPPA-Like polypeptides and agonists or antagonists.
    Type: Application
    Filed: April 7, 2008
    Publication date: August 21, 2008
    Applicant: Immunex Corporation
    Inventors: Timothy A. Bird, Mark E. Tometsko, William C. Dougall, Bruce A. Mosley
  • Hematopoietin receptors HPR1 and HPR2
    Publication number: 20080026402
    Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.
    Type: Application
    Filed: January 31, 2007
    Publication date: January 31, 2008
    Applicant: Immunex Corporation
    Inventors: David Cosman, Bruce Mosley, Timothy Bird, Robert DuBose, Steven Wiley
  • Antibodies to Interleukin-4 receptors and uses thereof
    Patent number: 7317090
    Abstract: Methods and comnositions related to antibodies that bind to mammalian Tnterleulcin-4 recentor proteins are disclosed.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: January 8, 2008
    Assignee: Immunex Corporation
    Inventors: Bruce A. Mosley, David J. Cosman, Linda S. Park, M. Patricia Beckmann, Carl J. March, Rejean Idzerda
  • Cytokine polypeptides
    Publication number: 20070081973
    Abstract: This invention relates to IMX129840 cytokines, including new mammalian cytokine polypeptides; to methods of making such polypeptides; to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors; and to methods of identifying compounds that alter IMX129840 cytokine polypeptide activities.
    Type: Application
    Filed: November 20, 2006
    Publication date: April 12, 2007
    Applicant: Immunex Corporation
    Inventors: Peter Baum, Bruce Mosley, Randal Ketchem, Scott Taylor
  • Human disintegrin protein
    Publication number: 20060292144
    Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 28, 2006
    Applicant: Immunex Corporation
    Inventors: Roy Black, Kurt Poindexter, Bruce Mosley, Robert DuBose, Steven Wiley
  • Human and murine cytokine polypeptides
    Publication number: 20060110772
    Abstract: This invention relates to IMX7189 cytokines and to new members of the human cytokine polypeptide family, methods of making such polypeptides, and to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to identify compounds that alter cytokine polypeptide activities.
    Type: Application
    Filed: July 7, 2005
    Publication date: May 25, 2006
    Applicant: Immunex Corporation
    Inventors: Peter Baum, Bruce Mosley, Randal Ketchem
  • Receptor for Oncostatin M
    Publication number: 20050260197
    Abstract: A novel polypeptide functions as the ? chain of an oncostatin M receptor and is thus designated OSM-R?. Heterodimeric receptor proteins comprising OSM-R? and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.
    Type: Application
    Filed: August 6, 2003
    Publication date: November 24, 2005
    Inventors: Bruce Mosley, David Cosman
  • Cytokine polypeptides
    Publication number: 20050233418
    Abstract: This invention relates to TMEM7 and TMEM7-related cytokines and to new members of the human cytokine polypeptide family, to methods of making such polypeptides, to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to methods of using them to identify compounds that alter cytokine polypeptide activities.
    Type: Application
    Filed: October 15, 2004
    Publication date: October 20, 2005
    Applicant: Immunex Corporation
    Inventors: Peter Baum, Bruce Mosley
  • Antibodies to interleukin-4 receptors and uses thereof
    Publication number: 20050118176
    Abstract: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
    Type: Application
    Filed: October 17, 2003
    Publication date: June 2, 2005
    Inventors: Bruce Mosley, David Cosman, Linda Park, M. Beckmann, Carl March, Rejean Idzerda
  • H14 DNA and polypeptides
    Publication number: 20050101768
    Abstract: DNA encoding H14 polypeptides and methods for using the encoded polypeptides are disclosed.
    Type: Application
    Filed: August 18, 2003
    Publication date: May 12, 2005
    Inventors: David Cosman, Bruce Mosley
  • Rank-ligand-induced sodium/proton antiporter polypeptides
    Publication number: 20040157771
    Abstract: This invention relates to RIPPA, a new member of the human Na+/H+ antiporter polypeptide family, methods of making such polypeptides, and to methods of using RIPPA and RIPPA-Like polypeptides and agonists or antagonists.
    Type: Application
    Filed: February 21, 2003
    Publication date: August 12, 2004
    Inventors: Timothy A. Bird, Mark E. Tometsko, William C. Dougall, Bruce A. Mosley
  • Hematopoietin receptor
    Publication number: 20040152161
    Abstract: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely inactivated; to methods of using HPR1 or HPR2 polypeptides to identify compounds that alter HPR1 or HPR2 polypeptide activities; and to methods of preparing medicaments for and/or treating conditions associated with hematopoietin receptor function.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 5, 2004
    Applicant: Immunex Corporation
    Inventors: David J. Cosman, Bruce A. Mosley, Robert F. DuBose, Steven R. Wiley
  • Antibodies to interleukin-4 receptors and uses thereof
    Patent number: 6716587
    Abstract: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: April 6, 2004
    Assignee: Immunex Corporation
    Inventors: Bruce A. Mosley, David J. Cosman, Linda S. Park, M. Patricia Beckmann, Carl J. March, Rejean Idzerda
  • Human disintegrin protein
    Publication number: 20040047854
    Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.
    Type: Application
    Filed: June 10, 2003
    Publication date: March 11, 2004
    Inventors: Roy A. Black, Kurt M. Poindexter, Bruce A. Mosley, Robert F. DuBose, Steven R. Wiley
  • Antibodies to interleukin-4 receptors and uses thereof
    Publication number: 20030185821
    Abstract: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
    Type: Application
    Filed: March 22, 2002
    Publication date: October 2, 2003
    Applicant: Immunex Corporation
    Inventors: Bruce A. Mosley, David J. Cosman, Linda S. Park, M. Patricia Beckman, Carl J. March, Rejean Idzerda
  • Human and murine cytokine polypeptides
    Publication number: 20030134306
    Abstract: This invention relates to IMX7189 cytokines and to new members of the human cytokine polypeptide family, methods of making such polypeptides, and to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to identify compounds that alter cytokine polypeptide activities.
    Type: Application
    Filed: October 2, 2002
    Publication date: July 17, 2003
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem
  • Receptor for oncostatin M
    Publication number: 20030109003
    Abstract: A novel polypeptide functions as the &bgr; chain of an oncostatin M receptor and is thus designated OSM-R&bgr;. Heterodimeric receptor proteins comprising OSM-R&bgr; and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.
    Type: Application
    Filed: December 6, 2002
    Publication date: June 12, 2003
    Applicant: Immunex Corporation
    Inventors: Bruce Mosley, David J. Cosman
  • Cytokine polypeptides
    Publication number: 20030104579
    Abstract: This invention relates to IMX129840 cytokines, including new mammalian cytokine polypeptides; to methods of making such polypeptides; to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors; and to methods of identifying compounds that alter IMX129840 cytokine polypeptide activities.
    Type: Application
    Filed: May 8, 2002
    Publication date: June 5, 2003
    Inventors: Peter R. Baum, Bruce A. Mosley, Randal R. Ketchem, Scott L. Taylor
  • Interleukin-4 receptors
    Patent number: 6548655
    Abstract: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 15, 2003
    Assignee: Immunex Corporation
    Inventors: Bruce Mosley, David J. Cosman, Linda Park, M. Patricia Beckmann, Carl J. March, Rejean Idzerda