Patents by Inventor Bruce A. Posner

Bruce A. Posner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20240043443
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monica Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Publication number: 20230285402
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230136730
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: August 2, 2022
    Publication date: May 4, 2023
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLUENZA
    Publication number: 20220073495
    Abstract: The present disclosure provides, in part, compositions, kits and methods for treating or preventing an influenza viral infection by administering a therapeutically effective amount of an inhibitor of influenza viral M mRNA nuclear export to a subject in need.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 10, 2022
    Applicant: The Board of Regents of The Universtiy of Texas System
    Inventors: Beatriz M.A. Fontoura, Matthew A. Esparza, Hanspeter Niederstrasser, Bruce Posner, Joseph M. Ready, Amir Mor
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20210106587
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: August 19, 2020
    Publication date: April 15, 2021
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20210094968
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: May 8, 2020
    Publication date: April 1, 2021
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20210032265
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 10869871
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: December 22, 2020
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sanford Markowitz, James K.V. Wilson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • NOVEL TFEB PATHWAY AGONISTS FOR METABOLIC DISEASES AND AGEING
    Publication number: 20200333357
    Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 22, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jinming GAO, Michael A. WHITE, Chensu WANG, Yang LI, Bruce POSNER, Gang HUANG
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20200140453
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: May 24, 2019
    Publication date: May 7, 2020
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS OF MODULATING SHIRT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20190365769
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 16, 2017
    Publication date: December 5, 2019
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Compositions and methods of modulating 15-PGDH activity
    Patent number: 10301320
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: May 28, 2019
    Assignees: University of Kentucky Research Foundation, Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Isoxazole treatments for frontotemporal dementia
    Patent number: 10149836
    Abstract: The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 11, 2018
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joachim Herz, Gang Yu, Bruce Posner, Basar Cenik
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20180118756
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: April 14, 2016
    Publication date: May 3, 2018
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 9789116
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: October 17, 2017
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee
  • Compositions and methods of modulating 15-PGDH activity
    Patent number: 9790233
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: October 17, 2017
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System, University of Kentucky Research Foundation
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce A. Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • ISOXAZOLE TREATMENTS FOR FRONTOTEMPORAL DEMENTIA
    Publication number: 20170172987
    Abstract: The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.
    Type: Application
    Filed: March 20, 2015
    Publication date: June 22, 2017
    Inventors: Joachim HERZ, Gang YU, Bruce POSNER, Basar CENIK
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20170173028
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 15, 2014
    Publication date: June 22, 2017
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Youngyou Zhang, Amar Desai, Stanton Gerson, William Greenlee
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20170165241
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 15, 2017
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Melissa Moss, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20150072998
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: April 16, 2013
    Publication date: March 12, 2015
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce A. Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Melissa Moss, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai