Patents by Inventor Bruce A. Shapiro

Bruce A. Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20190231633
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel Protector Packaging with Integrated Calf Sizing Device
    Publication number: 20190200704
    Abstract: A system (400) includes a package (401). A heel protector (402) is disposed within the package. The heel protector includes a leg engaging section (101) defining a leg insertion aperture (104), a fastener coupled to a first side of the leg engaging section, and a complementary fastener coupled to a second side of the leg engaging section. A measurement device (404) is incorporated into, but separable from, the package. The measurement device indicates whether the leg engaging section will fit a patient calf (302).
    Type: Application
    Filed: January 3, 2018
    Publication date: July 4, 2019
    Inventors: Michelle Drey, Bruce Shapiro
  • Multifunctional RNA nanoparticles and methods of use
    Patent number: 10301621
    Abstract: The instant invention provides RNA nanoparticles and R/DNA chimeric nanoparticles comprising one or more functionalities. The multifunctional RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 28, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Angelica N. Martins
  • Heel protector and corresponding rehabilitation systems and methods for using the same
    Patent number: 10292895
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: May 21, 2019
    Assignee: Medline Industries, Inc.
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20180161189
    Abstract: A device (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section and the foot engaging section define a leg insertion aperture (104). A compressible cushion layer (402) is disposed at least in the leg engaging section. At least one bolster tube (401) is disposed interior the leg engaging section. The bolster tube (401) can be selectively removable through one or more apertures (1105,1106).
    Type: Application
    Filed: February 8, 2018
    Publication date: June 14, 2018
    Inventors: Michelle Drey, Bruce Shapiro
  • Heel protector and corresponding rehabilitation systems and methods for using the same
    Patent number: 9980845
    Abstract: A device (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section and the foot engaging section define a leg insertion aperture (104). A compressible cushion layer (402) is disposed at least in the leg engaging section. At least one bolster tube (401) is disposed interior the leg engaging section. The bolster tube (401) can be selectively removable through one or more apertures (1105,1106).
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: May 29, 2018
    Assignee: Medline Industries, Inc.
    Inventors: Michelle Drey, Bruce Shapiro
  • TRIGGERING RNA INTERFERENCE WITH RNA-DNA AND DNA-RNA NANOPARTICLES
    Publication number: 20170274000
    Abstract: The instant invention provides RNA nanocubes, DNA nanocubes and R/DNA chimeric nanocubes comprising one or more functionalities. The multifunctional RNA nanocubes are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Application
    Filed: May 6, 2015
    Publication date: September 28, 2017
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard
  • RNA nanoparticles and nanotubes
    Patent number: 9732337
    Abstract: The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: August 15, 2017
    Assignees: The United Stated of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Yaroslava G. Yingling, Eckart Bindewald, Wojciech Kasprzak, Luc Jaeger, Isil Severcan, Cody Geary, Kirill Afonin
  • Co-transcriptional assembly of modified RNA nanoparticles
    Patent number: 9719084
    Abstract: A method is provided for generating RNA nanoparticles having modified nucleotides and/or having increased nuclease resistance where the RNA nanoparticles are formed cotranscriptionally by T7 RNA polymerase in the presence of manganese ions.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 1, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Maria L. Kireeva, Mikhail Kashlev, Luc Jaeger, Wade W. Grabow
  • MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS OF USE
    Publication number: 20170121708
    Abstract: The instant invention provides RNA nanoparticles and R/DNA chimeric nanoparticles comprising one or more functionalities. The multifunctional RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.
    Type: Application
    Filed: September 17, 2014
    Publication date: May 4, 2017
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Angelica N. Martins
  • Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP)
    Patent number: 9631192
    Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 25, 2017
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Eckart H. Bindewald, Luc Jaeger, Arti N. Santhanam
  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20160374892
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Application
    Filed: September 9, 2016
    Publication date: December 29, 2016
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel protector and corresponding rehabilitation systems and methods for using the same
    Patent number: 9439826
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: September 13, 2016
    Assignee: Medline Industries, Inc.
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20160058642
    Abstract: A device (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section and the foot engaging section define a leg insertion aperture (104). A compressible cushion layer (402) is disposed at least in the leg engaging section. At least one bolster tube (401) is disposed interior the leg engaging section. The bolster tube (401) can be selectively removable through one or more apertures (1105,1106).
    Type: Application
    Filed: August 26, 2014
    Publication date: March 3, 2016
    Inventors: Michelle Drey, Bruce Shapiro
  • THERAPEUTIC RNA SWITCHES COMPOSITIONS AND METHODS OF USE
    Publication number: 20150240238
    Abstract: The invention provides for therapeutic RNA switches comprising oligonucleotide sequences complementary to a trigger sequence, an antisense strand oligonucleotide, and a sense strand oligonucleotide complementary to a target nucleic acid molecule.
    Type: Application
    Filed: November 19, 2012
    Publication date: August 27, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bruce A. Shapiro, Eckart H. Bindewald, Kirill A. Afonin, Luc Jaeger, Arti N. Santhanam
  • CO-TRANSCRIPTIONAL ASSEMBLY OF MODIFIED RNA NANOPARTICLES
    Publication number: 20150203842
    Abstract: A method is provided for generating RNA nanoparticles having modified nucleotides and/or having increased nuclease resistance where the RNA nanoparticles are formed cotranscriptionally by T7 RNA polymerase in the presence of manganese ions.
    Type: Application
    Filed: September 6, 2013
    Publication date: July 23, 2015
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Maria L. Kireeva, Mikhail Kashlev, Luc Jaeger, Wade W. Grabow
  • AUTO-RECOGNIZING THERAPEUTIC RNA/DNA CHIMERIC NANOPARTICLES (NP)
    Publication number: 20140303237
    Abstract: Auto-recognizing therapeutic R/DNA chimeric nanoparticles (R/DNA NP) are described that are pairs of DNA/RNA hybrids where the DNA molecules have complementary toehold sequences that promote the re-association of the R/DNA NPs when mixed resulting in the formation of RNA/RNA duplexes that act as siRNAs.
    Type: Application
    Filed: November 19, 2012
    Publication date: October 9, 2014
    Inventors: Bruce A. Shapiro, Kirill A. Afonin, Mathias D. Viard, Eckart H. Bindewald
  • Heel Protector and Corresponding Rehabilitation Systems and Methods for Using the Same
    Publication number: 20140107547
    Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).
    Type: Application
    Filed: February 1, 2013
    Publication date: April 17, 2014
    Applicant: Medline Industries, Inc.
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel protector
    Patent number: D749744
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: February 16, 2016
    Assignee: Medline Industries, Inc.
    Inventors: Michelle Drey, Margaret Falconio-West, Bruce Shapiro
  • Heel support device
    Patent number: D780932
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 7, 2017
    Assignee: Medline Industries, Inc.
    Inventors: Michelle Drey, Bruce Shapiro