Patents by Inventor Bruce Alan Pfeffer

Bruce Alan Pfeffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small organic molecules that increase the activity of gelatinase a in ocular cells
    Patent number: 7071211
    Abstract: Small organic molecules capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: July 4, 2006
    Assignee: Bausch & Lomb Inc.
    Inventors: Bruce Alan Pfeffer, Rosemarie Beth Flick, Naveed Bin Kamal Shams, Stephen Paul Bartels
  • Small organic molecules that increase the activity of Gelatinase A in ocular cells
    Publication number: 20040068017
    Abstract: Small organic molecules capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.
    Type: Application
    Filed: September 27, 2002
    Publication date: April 8, 2004
    Inventors: Bruce Alan Pfeffer, Rosemarie Beth Flick, Naveed Bin Kamal Shams, Stephen Paul Bartels
  • Colorimetric assay system using thiopeptolide substrate for detection of membrane-type matrix metalloproteinase
    Publication number: 20020142362
    Abstract: A calorimetric assay system to measure the expression or activity of membrane-type matrix metalloproteinases using a thiopeptolide substrate. The subject colorimetric assay system is useful in screening pharmacological agents that may have therapeutic potential in the treatment of glaucoma and the promotion of wound healing. The subject colorimetric assay system is also useful in the discovery of new therapies for cancer and conditions involving neovascularization based on modulation of extracellular matrix.
    Type: Application
    Filed: May 23, 2000
    Publication date: October 3, 2002
    Inventors: Rosemarie Beth Flick, Bruce Alan Pfeffer, Naveed Bin Kamal Shams, Stephen Paul Bartels