Patents by Inventor Bruce Allen Pearlman

Bruce Allen Pearlman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of Gamma-Amino Acids Having Affinity for The Alpha-2-Delta Protein
    Publication number: 20090299093
    Abstract: Disclosed are materials and methods for preparing optically active ?-amino acids of Formula 1, which bind to the alpha-2-delta (?2?) subunit of a calcium channel.
    Type: Application
    Filed: July 31, 2009
    Publication date: December 3, 2009
    Inventors: Margaret Claire Evans, Lloyd Charles Franklin, Lorraine Michelle Murtagh, Thomas Norman Nanninga, Bruce Allen Pearlman, James Edward Saenz, Niamh Josephine Willis
  • PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN
    Publication number: 20090247743
    Abstract: Disclosed are materials and methods for preparing optically active ?-amino acids of Formula 1, which bind to the alpha-2-delta (?2?) subunit of a calcium channel.
    Type: Application
    Filed: June 27, 2005
    Publication date: October 1, 2009
    Inventors: Brian G Conway, Thomas Norman Nanninga, Hiafeng Wu, Garrett S. Hoge, Bruce Allen Pearlman, Derick Dale Winkle
  • 7?-Hydroxyacetyl and 7?-Hydroperoxyacetyl-substituted steroid compounds
    Patent number: 7417140
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 26, 2008
  • 7 ?-Enedione-substituted steroid compounds
    Patent number: 7414127
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 19, 2008
  • 7?-biscarbonyl-substituted steroid compounds
    Patent number: 7411062
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 12, 2008
  • Process to produce 19-nor-10?-carboxylic acids by fungal oxidation of 6-substituted-?6-pregnanes
    Patent number: 7300771
    Abstract: A process to produce 19-nor-10?-carboxylic acids by fungal oxidation of 6-substituted-?6-pregnanes is disclosed.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: November 27, 2007
    Assignee: Pfizer Inc.
    Inventors: Michael Jon White, Ivan Gale Gilbert, Bruce Allen Pearlman
  • Processes to prepare eplerenone
    Patent number: 7235655
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: June 26, 2007
  • Crystal form
    Patent number: 7112670
    Abstract: The present invention involves a novel crystal form of 17?-hydroxy-7?-(5?-methyl-2?-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, ?-lactone, having the formula which is an intermediate useful in preparation of an important pharmaceutical, eplerenone.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: September 26, 2006
    Assignee: Pharmacia Corporation
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz
  • Process to prepare oxazolidinones
    Patent number: 7087784
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: August 8, 2006
    Assignee: Pharmacia & Upjohn
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Process to prepare oxazolidinones
    Patent number: 6887995
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: May 3, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Process to prepare 11&bgr;, 17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate
    Patent number: 6828120
    Abstract: The present invention is a novel process for the transformation of 17&agr;-hydroxy-6&agr;-methylpregn-4-ene-3,20-dione 17-acetate (I) to 11&bgr;,17&agr;,21-trihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 21-acetate (VI)
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: December 7, 2004
    Assignee: Pharmacia and Upjohn Company
    Inventors: Bruce Allen Pearlman, Michael J. White, Ivan G. Gilbert
  • Process to prepare oxazolidinones
    Publication number: 20040220407
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Application
    Filed: March 25, 2004
    Publication date: November 4, 2004
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Process to produce 19-nor-10beta-carboxylic acids by fungal oxidation of 6-substituted-delta6-pregnanes
    Publication number: 20040175784
    Abstract: A process to produce 19-nor-10&bgr;-carboxylic acids by fungal oxidation of 6-substituted-&Dgr;6-pregnanes is disclosed.
    Type: Application
    Filed: January 20, 2004
    Publication date: September 9, 2004
    Inventors: Michael Jon White, Ivan Gale Gilbert, Bruce Allen Pearlman
  • Novel crystal form
    Publication number: 20040127702
    Abstract: The present invention involves a novel crystal form of 17&bgr;-hydroxy-7&agr;-(5′-methyl-2′-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, &ggr;-lactone, having the formula 1
    Type: Application
    Filed: September 19, 2003
    Publication date: July 1, 2004
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz
  • Process to produce oxazolidinones
    Patent number: 6740754
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: May 25, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Process to produce oxazolidinones
    Patent number: 6716980
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C•H(OH)—CH2—NH—CO—RN   (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: April 6, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Process to produce oxazolidinones
    Publication number: 20040006238
    Abstract: The present invention includes a number of novel intermediates such as the (S)secondary alcohol of formula (VIIIA)
    Type: Application
    Filed: June 27, 2003
    Publication date: January 8, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
    Publication number: 20040006240
    Abstract: The present invention is a novel process for the transformation of 11&bgr;,17&agr; dihydroxy-6&agr;-methylpregna-1,4-diene-3,20-dione 17-acetate (III) 1
    Type: Application
    Filed: April 18, 2003
    Publication date: January 8, 2004
    Inventor: Bruce Allen Pearlman
  • Process to prepare eplerenone
    Publication number: 20030232981
    Abstract: The present invention involves intermediates, including a 7&agr;-substituted steroid (II), 1
    Type: Application
    Filed: March 21, 2003
    Publication date: December 18, 2003
  • PROCESS TO PRODUCE OXAZOLIDINONES
    Publication number: 20030216572
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA)
    Type: Application
    Filed: April 24, 2003
    Publication date: November 20, 2003
    Applicant: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman