Patents by Inventor Bruce Andrew Kowalczyk

Bruce Andrew Kowalczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID SALT FORM OF ALPHA-6-MPEG6-O-HYDROXYCODONE AS OPIOID AGONISTS AND USES THEREOF
    Publication number: 20170226119
    Abstract: Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.
    Type: Application
    Filed: April 26, 2017
    Publication date: August 10, 2017
    Inventors: Patricia Andres, Yogesh Datar, Ramakrishna Gadiraju, Bruce Andrew Kowalczyk, Gabriel Christian Kuklis, Mahmoud Mirmehrabi, Nicholas Paschalides
  • Solid salt form of ?-6-mPEG-O-hydroxycodone as opioid agonists and uses thereof
    Patent number: 9682988
    Abstract: Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: June 20, 2017
    Assignee: Nektar Therapeutics
    Inventors: Patricia Andres, Yogesh Datar, Ramakrishna Gadiraju, Bruce Andrew Kowalczyk, Gabriel Christian Kuklis, Mahmoud Mirmehrabi, Nicholas Paschalides
  • Solid Salt Form of Alpha-6-MPEG6-O-Hydroxycodone as Opioid Agonists and Uses Thereof
    Publication number: 20150284402
    Abstract: Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 8, 2015
    Applicant: Nektar Therapeutics
    Inventors: Patricia Andres, Yogesh Datar, Ramakrishna Gadiraju, Bruce Andrew Kowalczyk, Gabriel Christian Kuklis, Mahmoud Mirmehrabi, Nicholas Paschalides
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 7141584
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 28, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20040122053
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6693200
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 17, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(Substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030229123
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: April 29, 2003
    Publication date: December 11, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6596876
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C);  and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030036655
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: May 31, 2002
    Publication date: February 20, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6472536
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: October 29, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6184242
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: February 6, 2001
    Assignee: Syntex USA (LLC)
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun