Patents by Inventor Bruce Baum

Bruce Baum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED GROWTH HORMONE
    Publication number: 20080008691
    Abstract: The invention provides a nucleic acid molecule encoding a growth hormone (GH) which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell.
    Type: Application
    Filed: September 6, 2007
    Publication date: January 10, 2008
    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT.
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce Baum, Christopher Snell
  • Hybrid adeno-retroviral vector for the transfection of cells
    Publication number: 20060035371
    Abstract: An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5? retroviral LTR nucleic acid sequence, a 3? retroviral LTR nucleic acid sequence, a nucleic acid sequence encoding a portion of a retroviral envelope protein adjacent to either the 5? LTR or the 3? LTR nucleic acid sequence, a retroviral packaging sequence and a nucleic acid sequence encoding a transgene located between the 5? LTR and the 3? LTR is provided. Host cells infected with this adenovirus are also provided. An adenoviral vector is provided that includes an adenoviral polynucleotide sequence comprising a nucleic acid encoding a transgene, a retroviral packaging signal, a 5? and a 3? retroviral LTR, and a portion of a retroviral envelope polypeptide, wherein the adenoviral polynucleotide sequence does not encode one or more of E1, E3 or E4.
    Type: Application
    Filed: October 19, 2005
    Publication date: February 16, 2006
    Inventors: Changyu Zheng, Brian O'Connell, Bruce Baum