Patents by Inventor Bruce Bondurant

Bruce Bondurant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiation sensitive liposomes
    Patent number: 8535712
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: September 17, 2013
    Assignees: Varian Medical Systems, Inc., Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
  • RADIATION SENSITIVE LIPOSOMES
    Publication number: 20130053618
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: September 10, 2012
    Publication date: February 28, 2013
    Applicant: Varian Medical Systems, Inc.
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
  • RADIATION SENSITIVE LIPOSOMES
    Publication number: 20110217236
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: October 11, 2010
    Publication date: September 8, 2011
    Applicant: Varian Medical Systems, Inc.
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
  • RADIATION SENSITIVE LIPOSOMES
    Publication number: 20090304589
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposome composition comprising a stable liposome-forming lipid and a polymerizable colipid, and a chain transfer agent. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: September 26, 2008
    Publication date: December 10, 2009
    Applicant: Varian Medical Systems,Inc.
    Inventors: Bruce Bondurant, Kathy A. McGovern, Robert M. Sutherland
  • Radiation sensitive liposomes
    Publication number: 20060099141
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing, radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: December 22, 2005
    Publication date: May 11, 2006
    Inventors: David O'Brien, Kathy McGovern, Bruce Bondurant, Robert Sutherland
  • Radiation sensitive liposomes
    Patent number: 6989153
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: January 24, 2006
    Assignees: Varian Medical Systems Technologies, Inc., Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
  • Stabilized biocompatible supported lipid membrane
    Publication number: 20060014013
    Abstract: A lipid membrane is self-assembled and stabilized at a solid surface by depositing a lipid monolayer or a lipid multilayer on a substrate, otaining a supported lipid monolayer or a supported lipid multilayer; and in situ polymerizing the supported lipid monolayer or the supported lipid multilayer, thereby obtaining a polymerized membrane.
    Type: Application
    Filed: March 11, 2002
    Publication date: January 19, 2006
    Inventors: Steven Saavedra, David Obrien, Eric Ross, Bruce Bondurant, John Conboy
  • Radiation sensitive liposomes
    Publication number: 20020064554
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: November 30, 2000
    Publication date: May 30, 2002
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland