Patents by Inventor Bruce C. Follows

Bruce C. Follows has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230365562
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 31, 2023
    Publication date: November 16, 2023
    Inventors: Nello MAINOLFI, Chris DE SAVI, Matthew M. WEISS, Xiao ZHU, Xiaozhang ZHENG, Bruce C. FOLLOWS
  • Inhibitors of protein tyrosine phosphatase 1B
    Patent number: 7521473
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: April 21, 2009
    Assignee: Wyeth
    Inventors: Jinbo Lee, Zhao-Kui Wan, Douglas P. Wilson, Bruce C. Follows, Steven J. Kirincich, Michael J. Smith, Jun-Jun Wu, Kenneth W. Foreman, David V. Erbe, Yan-Ling Zhang, Weixin Xu, Steve Y. Tam
  • Inhibitors of Protein Tyrosine Phosphatase 1B
    Publication number: 20090048286
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Application
    Filed: September 23, 2008
    Publication date: February 19, 2009
    Applicant: Wyeth
    Inventors: Jinbo Lee, Steven J. Kirincich, Michael J. Smith, Douglas P. Wilson, Bruce C. Follows, Zhao-Kui Wan, Diane M. Joseph-McCarthy, David V. Erbe, Yan-Ling Zhang, Weixin Xu, Steve Y. Tam