Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: The present invention provides 75 kD transmembrane neurotrophin receptor (p75NTR) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.

Abstract: An apparatus for communicating with a downhole tool includes a sensor body including at least two electrodes electrically insulated from one another and an external control device configured to engage the two electrodes. Detection circuitry connected to the two electrodes is configured to monitor an electrical status across the two electrodes, through the external control device, and upon detecting a change in electrical status that matches a predefined pattern, communicate a command to power management circuitry to alter a power status of the downhole tool.

Abstract: A Violin & Bow Primer having a bow guide and a guide housing that is adjustable to accurately mimic the bow stroke angle for the four strings of the violin G, D, A, and E is provided.

Abstract: The present invention provides 75 kD transmembrane neurotrophin receptor (p75NTR) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.

Abstract: A method, system, and computer program product for on-chip control of thermal cycling in an integrated circuit (IC) are provided in the illustrative embodiments. A first circuit is configured on the IC for adjusting a first voltage being applied to a first part of the IC. A first temperature of the first part is measured at a first time. A determination is made that the first temperature is outside a temperature range defined by an upper temperature threshold and a lower temperature threshold. The first voltage is adjusted by reducing the first voltage when the first temperature exceeds the upper temperature threshold and by increasing the first voltage when the first temperature is below the lower temperature threshold, thereby causing the first temperature of the first part to attain a value within the temperature range.

Abstract: A system, and computer usable program product for fast remote communication and computation between processors are provided in the illustrative embodiments. A direct core to core communication unit (DCC) is configured to operate with a first processor, the first processor being a remote processor. A memory associated with the DCC receives a set of bytes, the set of bytes being sent from a second processor. An operation specified in the set of bytes is executed at the remote processor such that the operation is invoked without causing a software thread to execute.

Abstract: A set of routing rules is receiving at a networking device in a data communication network from a controller in the data communication network implemented using the software-defined network architecture. A condition is detected at the networking device. A subset of the set of routing rules is selected in the networking device. The selecting is responsive to the condition. The subset of routing rules is applied in the networking device at a first time such that the networking device uses a first routing rule to route data traffic in the data communication network, and omits using a second routing rule received from the controller to route data traffic in the data communication network. A second subset of routing rules from the set of routing rules responsive to a second condition is applied autonomously at a second time at the networking device.

Abstract: A bottom hole assembly attached to a drillstring includes a main body including multiple electrical insulator sections along a length thereof, each of the electrical insulator sections configured to have a voltage difference generated there across, wherein a transmitting electrical insulator section having a voltage difference generated there across is configured to remain open, and wherein all remaining electrical insulator sections are configured to be electrically shorted there across.

Abstract: An apparatus for communicating with a downhole tool includes a sensor body including at least two electrodes electrically insulated from one another and an external control device configured to engage the two electrodes. Detection circuitry connected to the two electrodes is configured to monitor an electrical status across the two electrodes, through the external control device, and upon detecting a change in electrical status that matches a predefined pattern, communicate a command to power management circuitry to alter a power status of the downhole tool.

Abstract: A set of routing rules is receiving at a networking device in a data communication network from a controller in the data communication network implemented using the software-defined network architecture. A condition is detected at the networking device. A subset of the set of routing rules is selected in the networking device. The selecting is responsive to the condition. The subset of routing rules is applied in the networking device at a first time such that the networking device uses a first routing rule to route data traffic in the data communication network, and omits using a second routing rule received from the controller to route data traffic in the data communication network. A second subset of routing rules from the set of routing rules responsive to a second condition is applied autonomously at a second time at the networking device.

Abstract: A bottom hole assembly attached to a drillstring includes a main body including multiple electrical insulator sections along a length thereof, each of the electrical insulator sections configured to have a voltage difference generated there across, wherein a transmitting electrical insulator section having a voltage difference generated there across is configured to remain open, and wherein all remaining electrical insulator sections are configured to be electrically shorted there across.

Abstract: A method for fast remote communication and computation between processors is provided in the illustrative embodiments. A direct core to core communication unit (DCC) is configured to operate with a first processor, the first processor being a remote processor. A memory associated with the DCC receives a set of bytes, the set of bytes being sent from a second processor. An operation specified in the set of bytes is executed at the remote processor such that the operation is invoked without causing a software thread to execute.

Abstract: A method for improving the performance of a digital circuit is provided in the illustrative embodiments. A real frequency of operation of the digital circuit is adjusted using a control loop in the digital circuit, the adjusting the real frequency being responsive to a change in an operating condition of the digital circuit. A measurement of a current drawn by the digital circuit is received from a voltage regulator supplying electrical power to the digital circuit. An over-current target current value is received. A voltage output from the voltage regulator to the digital circuit is adjusted such that the current drawn by the digital circuit does not exceed the over-current target current value.

Abstract: A system, and computer program product for increasing a capacity of a memory are provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.

Abstract: A method for increasing a capacity of a memory is provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.

Abstract: A method, system, and computer program product for compacting a non-biased results multiset are provided in the illustrative embodiments. A set of references and a multiset of values are identified. The multiset includes a first and a second set of values, each set including a first value. A first reference in the set of references refers to the first set of values and a second reference in the set of references refers to the second set of values. The values in the first and second set of values are re-arranged to form permuted first and second sets of values. The multiset is compacted by overlaying the permuted first and second sets of values in a portion such that the permuted first set of values and the permuted second set of values share a single instance of the first value in a portion of the compacted multiset.

Abstract: A system and method for scheduling and executing jobs in a decentralized multifunction device (MFD) network is provided. The method includes receiving at an origin node of the network of MFDs a job, where the job includes data and a request to perform an operation on the data. MFDs of the network are selected to execute the requested operation on at least a portion of the job data. Portions of the job data are apportioned to the selected MFDs for processing thereof by executing the requested operation. The selecting and the apportioning are performed using historical information related to previous performance and reliability of the MFDs of the network.

Abstract: A system, and computer program product for increasing a capacity of a memory are provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.

Abstract: A method for increasing a capacity of a memory is provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.