Abstract: The present disclosure provides automated modules and instruments for improved detection of nuclease genome editing of live cells. The disclosure provides improved modules—including high throughput modules—for screening cells that have been subjected to editing and identifying and selecting cells that have been properly edited.

Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Abstract: An inflatable bone tamp for performing a minimally invasive surgical procedure includes a shaft having a primary region and a reduced diameter region, and an inflatable structure surrounding at least a portion of the reduced diameter region. The reduced diameter region of the shaft allows the deflated size of the inflatable structure to be minimized, while at the same time eliminating the need for the conventional dual lumen balloon catheter construction.

Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.

Abstract: An apparatus and method for mixing and dispensing bone cement is provided. The apparatus includes a mixing vessel for mixing bone cement attached to a syringe body. The syringe body having a lumen that is connected to the mixing vessel by a passageway between the mixing vessel and the lumen of the syringe body. A separator is provided between the mixing vessel and the syringe body and includes an orifice therein so that when the opening in the separator is misaligned with the lumen the passageway is blocked and when aligned the passageway is continuous with the lumen so that bone cement can pass into the syringe body. A plunger is provided and is slideably movable along the longitudinal axis of the syringe body so as to advance the bone cement out of the distal end of the syringe.

Abstract: An inflatable bone tamp for performing a minimally invasive surgical procedure includes a shaft having a primary region and a reduced diameter region, and an, inflatable structure surrounding at least a portion of the reduced diameter region. The reduced diameter region of the shaft allows the deflated size of, the inflatable structure to be minimized, while at the same time eliminating the need for the conventional dual lumen balloon catheter construction.

Abstract: An inflatable bone tamp for performing a minimally invasive surgical procedure includes a shaft having a primary region and a reduced diameter region, and an inflatable structure surrounding at least a portion of the reduced diameter region. The reduced diameter region of the shaft allows the deflated size of the inflatable structure to be minimized, while at the same time eliminating the need for the conventional dual lumen balloon catheter construction.

Abstract: An inflatable bone tamp for performing a minimally invasive surgical procedure includes an outer shaft defining an internal lumen, an inflatable structure coupled to the outer shaft, and an inner shaft movably disposed within the internal lumen and coupled to a distal end region of the inflatable structure. The internal lumen is sized to receive the inflatable structure, such that by moving the inner shaft relative to the outer shaft, the inflatable structure can be retracted into the internal lumen (and likewise can be extended from within the internal lumen for deployment in bone). This retraction capability can beneficially protect the inflatable structure during positioning/removal, and can also enhance recovery from radial tears of the inflatable structure.

Abstract: An apparatus and method for mixing and dispensing bone cement is provided. The apparatus includes a mixing vessel for mixing bone cement attached to a syringe body. The syringe body having a lumen that is connected to the mixing vessel by a passageway between the mixing vessel and the lumen of the syringe body. A separator is provided between the mixing vessel and the syringe body and includes an orifice therein so that when the opening in the separator is misaligned with the lumen the passageway is blocked and when aligned the passageway is continuous with the lumen so that bone cement can pass into the syringe body. A plunger is provided and is slideably movable along the longitudinal axis of the syringe body so as to advance the bone cement out of the distal end of the syringe.

Abstract: An apparatus and method for mixing and dispensing bone cement is provided. The apparatus includes a mixing vessel for mixing bone cement attached to a syringe body. The syringe body having a lumen that is connected to the mixing vessel by a passageway between the mixing vessel and the lumen of the syringe body. A separator is provided between the mixing vessel and the syringe body and includes an orifice therein so that when the opening in the separator is misaligned with the lumen the passageway is blocked and when aligned the passageway is continuous with the lumen so that bone cement can pass into the syringe body. A plunger is provided and is slideably movable along the longitudinal axis of the syringe body so as to advance the bone cement out of the distal end of the syringe.

Abstract: An injectable, flexible interspinous process device and a delivery system. The interspinous process device is flexible and can be fillable in situ with a desired amount of biocompatible material. The interspinous process device has a container portion. A support element, such as a self-expanding mesh, is used in conjunction with the container to provide added structural support. The mesh also facilitates deployment of the device when it is properly positioned. A conduit may be coupled to the interspinous process to fill the device. A delivery system is also provided for delivering the flexible interspinous process device to the desired location. The delivery system includes an outer catheter that is disposed over the interspinous process device to maintain it in the undeployed state and thus facilitate delivery of the device to the desired location. An inner removable sleeve and a guidewire may also be used with the delivery system.

Abstract: Devices for cutting an intervertebral disc that may include an elongated shape with a distal end and a proximal end and being sized for insertion into an intervertebral space. The devices may include a number of articulating segments that are movably connected together to be shaped in a variety of angular orientations to conform to the shape of the intervertebral disc. The segments may include one or more exposed cutting surfaces that cut the disc as the device is moved through the intervertebral space.

Abstract: A surgical instrument and/or method of using a surgical instrument during spinal surgery. The surgical instrument may find particular applicability to spinal implants for the intervertebral disc space that require relative rotation between parts in order to change the height of the implant. The instrument includes a knob that rotatable and selectively longitudinally moveable relative to a handle section. In a forward position, turning the knob turns a drive shaft that is coupled to the rotatable actuator of the implant, and causes the implant to expand or retract depending on the direction of rotation. In the rearward position, the drive shaft is retracted, and turning the knob turns a coupling shaft, distinct from the drive shaft, for decoupling the implant from the instrument.

Abstract: An apparatus and method for mixing and dispensing bone cement is provided. The apparatus includes a mixing vessel for mixing bone cement attached to a syringe body. The syringe body having a lumen that is connected to the mixing vessel by a passageway between the mixing vessel and the lumen of the syringe body. A separator is provided between the mixing vessel and the syringe body and includes an orifice therein so that when the opening in the separator is misaligned with the lumen the passageway is blocked and when aligned the passageway is continuous with the lumen so that bone cement can pass into the syringe body. A plunger is provided and is slideably movable along the longitudinal axis of the syringe body so as to advance the bone cement out of the distal end of the syringe.

Abstract: A cannula assembly and related methods of use. The cannula assembly includes a cannula and a stylet. The cannula has an outer surface that is non-circular. Rotation of the cannula about its longitudinal axis changes the orientation of the cannula's larger outer dimension so that the cannula may be used as a distraction tool. Rotation is effected by rotating a stylet handle, which rotates the associated stylet shaft, which in turn rotates the cannula. Related methods include rotating a handle of the stylet, while the shaft of the stylet is disposed in the bore of the cannula, about the first longitudinal axis so as to rotate the cannula about the longitudinal axis to distract vertebral bodies.