Patents by Inventor Bruce Chesebro

Bruce Chesebro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies for detection of friend murine leukemia virus
    Patent number: 6403300
    Abstract: The present invention relates to Friend murine leukemia virus (F-MuLV) specific monoclonal antibodies, or binding fragments thereof, specific for an antigenic determinant of a gp85 envelope precursor protein characteristic of a methanol-fixed F-MuLV infected cell. The invention also relates to hybridomas resulting from the fusion of myeloma cells and spleen cells, which hybridomas produce a Friend murine leukemia virus (F-MuLV) specific monoclonal antibody specific for an antigenic determinant of a gp85 envelope precursor protein characteristic of a methanol-fixed F-MuLV infected cell. The invention further relates to kits containing the above-described monoclonal antibodies.
    Type: Grant
    Filed: May 2, 1991
    Date of Patent: June 11, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael N. Robertson, Bruce Chesebro, Masaaki Miyazawa, William J. Britt
  • Cell lines useful for detection of human immunodeficiency virus
    Patent number: 5811282
    Abstract: The present invention relates to a method for AIDS diagnosis and monitoring of anti-AIDS drug therapy, and more particularly to a method of assaying for human immunodeficiency virus. The present invention uses a focal immunoassay (FIA) which utilizes HIV-specific antibodies and indirect immunoassay techniques to detect local areas of HIV infection in susceptible target cells growing in monolayers on plastic dishes. The present invention further relates to specific cell lines used as the susceptible target cells in the disclosed methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: The Unites States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Bruce Chesebro, Kathy Wehrly