Patents by Inventor Bruce D. Dorsey

Bruce D. Dorsey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210052585
    Abstract: The present invention includes substituted 3,3?bis(phenoxymethyl)-1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Application
    Filed: March 29, 2019
    Publication date: February 25, 2021
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Yi Fan, Christopher Brooks Moore, Duyan Nguyen
  • Patent number: 10919875
    Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 16, 2021
    Assignee: 89BIO LTD
    Inventors: Nadine C. Becknell, Reddeppa Reddy Dandu, Bruce D. Dorsey, Dimitar B. Gotchev, Robert L. Hudkins, Linda Weinberg, Craig A. Zificsak
  • Publication number: 20210032246
    Abstract: The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.
    Type: Application
    Filed: April 11, 2019
    Publication date: February 4, 2021
    Inventors: Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Duyan Nguyen, Mahesh Kumar Pallerla, Ganapati Reddy Pamulapati
  • Publication number: 20210017186
    Abstract: The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.
    Type: Application
    Filed: March 11, 2019
    Publication date: January 21, 2021
    Applicant: Arbutus Biopharma Corporation
    Inventors: Shuai Chen, Bruce D. Dorsey, Yi Fan, Dimitar B. Gotchev, Jorge Quintero
  • Patent number: 10851057
    Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: December 1, 2020
    Assignee: 89BIO LTD
    Inventors: Nadine C. Becknell, Reddeppa Reddy Dandu, Bruce D. Dorsey, Dimitar B. Gotchev, Robert L. Hudkins, Linda Weinberg, Craig A. Zificsak, Allison L. Zulli
  • Patent number: 10821103
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: November 3, 2020
    Assignee: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • Publication number: 20200261432
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 20, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • Publication number: 20200165213
    Abstract: The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
    Type: Application
    Filed: April 24, 2018
    Publication date: May 28, 2020
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Christopher Brooks Moore
  • Publication number: 20200124071
    Abstract: Systems, methods, and devices of the various embodiments may provide a joint suitable for use with space systems, such as robotic space systems, (e.g., Extra Vehicular Activity (EVA) space systems, Intra Vehicular Activity (IVA) space systems, etc.), etc. Various embodiments provide a joint configured to enable structural connection of structural elements, such as trusses, antenna boom sections, beams, etc., including cantilevered elements. Various embodiments provide a joint configured to enable connection of truss structure sections. Various embodiments may provide a robotic erectable joint including an active joint half and a passive joint half configured to connect to the active joint half to thereby form the robotic erectable joint when so connected, wherein the robotic erectable joint has a noncircular cross section (e.g., polygon (e.g., square, triangle, hexagon, etc.) cross section, oval cross section, ellipse cross section, etc.).
    Type: Application
    Filed: October 22, 2019
    Publication date: April 23, 2020
    Inventors: William R. Doggett, BRUCE D. KING, JOHN T DORSEY, STEPHEN J. HALES, CHRISTOPHER S. DOMACK
  • Patent number: 10569415
    Abstract: A manipulator includes first and second link arms which are connected together by a hinge. A cable actuation and tensioning system is provided between the link arms and includes a spreader arm, a driven element attached to each link arm and a cable engaged with the respective driven element and attached to the spreader arm. At least one of the arms, or all of the arms, can telescope to shorten or lengthen the arm(s) by movement of the system. The spreader arm may also be configured to slide relative to the first and second link arms to change the position of the spreader arm relative to the first and second link arms.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: February 25, 2020
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: William R. Doggett, John T. Dorsey, Thomas C. Jones, Bruce D. King
  • Patent number: 10550084
    Abstract: The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 4, 2020
    Assignee: Arbutus Biopharma Corporation
    Inventors: Ramesh Kakarla, Bruce D. Dorsey
  • Publication number: 20200031797
    Abstract: Described herein arc 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein arc methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
    Type: Application
    Filed: June 17, 2016
    Publication date: January 30, 2020
    Inventors: Nadine C. BECKNELL, Reddeppa Reddy DANDU, Bruce D. DORSEY, Dimitar B. GOTCHEV, Robert L. HUDKINS, Linda WEINBERG, Craig A. ZIFICSAK
  • Publication number: 20200024226
    Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.
    Type: Application
    Filed: March 20, 2018
    Publication date: January 23, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Ramesh Kakarla, Steven Kultgen, Jorge Quintero
  • Publication number: 20190314347
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: November 3, 2017
    Publication date: October 17, 2019
    Inventors: Danielle Lauren BAILEY, Yingzhi BI, Shuai CHEN, Bruce D. DORSEY, Dimitar B. GOTCHEV, Richard James HOLLAND, Ramesh KAKARLA, Duyan NGUYEN, Mark Christopher WOOD
  • Patent number: 10414763
    Abstract: The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: September 17, 2019
    Assignee: Cancer Research Technology Limited
    Inventors: Bruce D. Dorsey, Benjamin J. Dugan, Katherine M. Fowler, Robert L. Hudkins, Eugen F. Mesaros, Nathaniel J T Monck, Emma L. Morris, Ikeoluwa Olowoye, Gregory R. Ott, Gregoire A. Pave, Jonathan R. A. Roffey, Christelle N. Soudy, Craig A. Zificsak, Allison L. Zulli
  • Patent number: 10358447
    Abstract: The present invention includes novel substituted 2-N-hydroxy-1,3-dioxo-1,2,3,4-tetrahydronaphthyridines, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: July 23, 2019
    Assignee: Arbutus Biopharma Corporation
    Inventors: Ramesh Kakarla, Bruce D. Dorsey
  • Publication number: 20190169128
    Abstract: The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Inventors: RAMESH KAKARLA, BRUCE D. DORSEY
  • Publication number: 20190169185
    Abstract: The present invention includes novel substituted 2-N-hydroxy-1,3-dioxo-1,2,3,4-tetrahydronaphthyridines, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Inventors: RAMESH D. KAKARLA, BRUCE D. DORSEY
  • Publication number: 20190152913
    Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
    Type: Application
    Filed: January 25, 2019
    Publication date: May 23, 2019
    Inventors: Nadine C. Becknell, Reddeppa Reddy Dandu, Bruce D. Dorsey, Dimitar B. Gotchev, Robert L. Hudkins, Linda Weinberg, Craig A. Zificsak, Allison L. Zulli
  • Publication number: 20190151317
    Abstract: This application describes the use of the compound or a salt thereof, either alone or in combination with other therapeutically active agents, for the treatment of particular cancers, including any solid or hematological cancer in which AXL or c-Met is over-expressed.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 23, 2019
    Applicant: IGNYTA, INC.
    Inventors: Thelma S. ANGELES, Mark A. ATOR, Mangeng M. CHENG, Bruce D. DORSEY, Robert L. HUDKINS, Bruce A. RUGGERI