Patents by Inventor Bruce D. Johnson

Bruce D. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11207519
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 28, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael j. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Publication number: 20210339168
    Abstract: A cyclonic inlet diverter for initiating the separation of a multi-phase inlet fluid flow comprises an enclosed tubular body mounted crosswise within a larger separator vessel. The inlet diverter includes a splitter plate positioned within a center portion of the tubular body and configured to split the inlet flow into a first stream and a second stream, and a swirl plate positioned on each side of the splitter plate with angled surfaces configured to increase the cyclonic motion of the first and second streams within the tubular body. The inlet diverter further includes elongate apertures formed through bottom sidewall portions of the tubular body on each side of the splitter plate, an axial aperture formed through opposing end caps of the tubular body, and at least one radial aperture formed through lateral sidewall portions of the tubular body proximate each opposing end cap.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Applicant: EnXL LLC
    Inventor: Bruce D. Johnson
  • Publication number: 20210308396
    Abstract: Aspects discussed herein relate to remixing devices that can be used to modify a gas mix being inhaled by a user. The device can accurately adjust inspired CO2 and/or O2 levels independently to a desired level. Aspects described herein generally improve the quality, efficiency, and speed of devices to provide breathing gas mixes. Medical conditions can be diagnosed and a therapeutically effective gas mix can be provided as treatment for diagnosed medical conditions.
    Type: Application
    Filed: April 6, 2021
    Publication date: October 7, 2021
    Inventors: J. Hunter Downs, III, Bruce D. Johnson
  • Patent number: 11065559
    Abstract: A cyclonic inlet diverter for initiating the separation of a multi-phase inlet fluid flow comprises an enclosed tubular body mounted crosswise within a larger separator vessel. The inlet diverter includes a splitter plate positioned within a center portion of the tubular body and configured to split the inlet flow into a first stream and a second stream, and a swirl plate positioned on each side of the splitter plate with angled surfaces configured to increase the cyclonic motion of the first and second streams within the tubular body. The inlet diverter further includes elongate apertures formed through bottom sidewall portions of the tubular body on each side of the splitter plate, an axial aperture formed through opposing end caps of the tubular body, and at least one radial aperture formed through lateral sidewall portions of the tubular body proximate each opposing end cap.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 20, 2021
    Assignee: EnXL LLC
    Inventor: Bruce D. Johnson
  • Patent number: 11007458
    Abstract: A separation system for separating the components of a multi-phase fluid includes at least three tanks coupled together in series, with each tank enclosing a column of multi-phase fluid and having a tubular center riser that is divided into a distribution section and a gathering section, and with each center riser being configured to established a fluid circulation pattern having a radially-outward travel first leg, a vertical travel second leg, and a radially-inward travel third leg within the corresponding column of multi-phase fluid that is configured to separate at least one of a gas component, an oil component, and a particulate matter component from a water component of the multi-phase fluid, and with the height of the columns of multi-phase fluid in the first tank and the second tank being substantially equal to each other and determined by the height of a pour-over opening in the center riser of the third tank.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 18, 2021
    Assignee: EnXL LLC
    Inventor: Bruce D. Johnson
  • Publication number: 20210138362
    Abstract: A separation system for separating components of a flow of multi-phase fluid includes an elongate separator vessel oriented on an incline to define a lower inlet end having an inlet for receiving the fluid flow, a raised outlet end, and an inclined top inner surface extending from the inlet end to the outlet end. The system includes a lower weir plate positioned above the inlet end and an upper weir plate positioned below the outlet end having an upper edge defining a liquid level within the separator vessel, thereby allowing a lighter fluid component to flow over the upper edge into a upper section located forwardly of the upper weir plate. The system also includes a clear water pipe with a withdrawal opening positioned below the upper weir plate. The incline of the separator vessel is adjustable in accordance with the composition of the multi-phase fluid.
    Type: Application
    Filed: October 8, 2020
    Publication date: May 13, 2021
    Applicant: EnXL LLC
    Inventor: Bruce D. Johnson
  • Publication number: 20210113698
    Abstract: The present invention relates to bulk dry compositions comprising polyethylene glycol and an additive, such as a flavoring agent and/or sweetener, wherein the additive remains at a consistent concentration throughout the bulk composition. The invention also relates to processes for preparing the bulk dry compositions comprising polyethylene glycol.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Inventors: Lisa Kay Lupton, Kiran Kumar Muppireddy, Inderdeep Bhatia, Carlos O. Paz, Bruce D. Johnson
  • Patent number: 10918292
    Abstract: Non-invasive systems can be used to estimate cardiac output and stroke volume. For example, this document provides cuff occlusion systems and methods for their use so that cardiac output and stroke volume can be estimated in a non-invasive fashion. In some implementations, a patient's brachial artery is occluded by an inflatable cuff device for a period of time. A heart rate and a plurality of blood pressure pulse wave measurement curves can be measured using the cuff device. The data collected can be used to calculate an estimate of the patient's cardiac output and stroke volume.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: February 16, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Pavol Sajgalik, Vaclav Kremen, Bruce D. Johnson
  • Patent number: 10898121
    Abstract: A personal physical conditioning system, for a single, full-size human subject, has a sealable chamber that is configured to allow entry therein and occupancy thereof by the entirety of the single, full-size human subject and to allow the subject to exercise in a standing position using an item of physical conditioning equipment entirely contained within the sealable chamber. The system also has a ventilation system, including a pump, operable to change air in the sealable chamber and to establish, within the sealable chamber, a desired non-zero air pressure level of less than 1 atmosphere and down to pressure conditions substantially equivalent to an elevation of 25,000 feet above sea level. Related methods are also provided.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: January 26, 2021
    Assignee: Stratosphere ATC LLC
    Inventors: Robert Paul Williams, Bruce D. Johnson
  • Publication number: 20200230522
    Abstract: A cyclonic inlet diverter for initiating the separation of a multi-phase inlet fluid flow comprises an enclosed tubular body mounted crosswise within a larger separator vessel. The inlet diverter includes a splitter plate positioned within a center portion of the tubular body and configured to split the inlet flow into a first stream and a second stream, and a swirl plate positioned on each side of the splitter plate with angled surfaces configured to increase the cyclonic motion of the first and second streams within the tubular body. The inlet diverter further includes elongate apertures formed through bottom sidewall portions of the tubular body on each side of the splitter plate, an axial aperture formed through opposing end caps of the tubular body, and at least one radial aperture formed through lateral sidewall portions of the tubular body proximate each opposing end cap.
    Type: Application
    Filed: December 20, 2019
    Publication date: July 23, 2020
    Applicant: EnXL LLC
    Inventor: Bruce D. Johnson
  • Publication number: 20200179411
    Abstract: The invention is directed to pharmaceutical compositions for suspending bismuth subsalicylate and methods of use thereof. Formulations of the present invention include at least three-gum systems to prevent the settling out of heavy particles in solution and do not include magnesium aluminum silicate. The pharmaceutical compositions may be used to treat gastrointestinal disorders.
    Type: Application
    Filed: August 24, 2018
    Publication date: June 11, 2020
    Inventors: Inderdeep S. BHATIA, David R. CASSIDAY, Bruce D. JOHNSON, Carlos O. PAZ
  • Publication number: 20200114282
    Abstract: A separation system for separating the components of a multi-phase fluid includes at least three tanks coupled together in series, with each tank enclosing a column of multi-phase fluid and having a tubular center riser that is divided into a distribution section and a gathering section, and with each center riser being configured to established a fluid circulation pattern having a radially-outward travel first leg, a vertical travel second leg, and a radially-inward travel third leg within the corresponding column of multi-phase fluid that is configured to separate at least one of a gas component, an oil component, and a particulate matter component from a water component of the multi-phase fluid, and with the height of the columns of multi-phase fluid in the first tank and the second tank being substantially equal to each other and determined by the height of a pour-over opening in the center riser of the third tank.
    Type: Application
    Filed: October 10, 2019
    Publication date: April 16, 2020
    Applicant: EnXL LLC
    Inventor: Bruce D. Johnson
  • Publication number: 20200022592
    Abstract: Non-invasive systems and techniques can be used to accurately measure blood pressures of patients being supported by continuous flow left ventricular assist devices. For example, this document describes cuff occlusion devices and methods for their use so that the blood pressure and pulsatility of patients with significantly reduced pulsatility as a result of continuous flow left ventricular assist device support can be accurately measured in a non-invasive fashion.
    Type: Application
    Filed: January 9, 2018
    Publication date: January 23, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Pavol Sajgalik, Vaclav Kremen, Lyle D. Joyce, John A. Schirger, Bruce D. Johnson, Troy J. Cross, Vratislav Fabian
  • Publication number: 20190269923
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Application
    Filed: May 21, 2019
    Publication date: September 5, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Michael j. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Publication number: 20190167121
    Abstract: Non-invasive systems can be used to estimate cardiac output and stroke volume. For example, this document provides cuff occlusion systems and methods for their use so that cardiac output and stroke volume can be estimated in a non-invasive fashion. In some implementations, a patient's brachial artery is occluded by an inflatable cuff device for a period of time. A heart rate and a plurality of blood pressure pulse wave measurement curves can be measured using the cuff device. The data collected can be used to calculate an estimate of the patient's cardiac output and stroke volume.
    Type: Application
    Filed: July 18, 2017
    Publication date: June 6, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Pavol Sajgalik, Vaclav Kremen, Bruce D. Johnson
  • Patent number: 10300281
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: May 28, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael J. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Publication number: 20190076076
    Abstract: A personal physical conditioning system, for a single, full-size human subject, has a sealable chamber that is configured to allow entry therein and occupancy thereof by the entirety of the single, full-size human subject and to allow the subject to exercise in a standing position using an item of physical conditioning equipment entirely contained within the sealable chamber. The system also has a ventilation system, including a pump, operable to change air in the sealable chamber and to establish, within the sealable chamber, a desired non-zero air pressure level of less than 1 atmosphere and down to pressure conditions substantially equivalent to an elevation of 25,000 feet above sea level. Related methods are also provided.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 14, 2019
    Inventors: Robert Paul Williams, Bruce D. Johnson
  • Patent number: 10219734
    Abstract: A personal exercise apparatus that allows simultaneous simulation of mild to high altitude environments with algorithmically driven environmental stressors that may be pre-programmed or personally developed via physiological feedback during training. Additional stressors include an ability to transiently alter pressure in a chamber of the personal exercise apparatus at variable frequencies and amplitudes with a range of changes with an option of random pressure oscillations designed to personalize training programs. The additional stressors further include small variations in inspired CO2 levels and temperature allowing individuals to simulate breathing and temperature conditions in preparation for desired environmental conditions.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: March 5, 2019
    Assignee: Stratosphere ATC LLC
    Inventors: Robert Paul Williams, Bruce D. Johnson
  • Publication number: 20160166176
    Abstract: This document provides systems and techniques that can be used to provide computer-implemented interpretation (e.g., up-to-date, on demand, and real time interpretation) of respiratory profiles of patients using, for example, an application provided by a computer server system, to assess a patient's cardiac and/or pulmonary function.
    Type: Application
    Filed: July 23, 2014
    Publication date: June 16, 2016
    Inventors: Bruce D. Johnson, Thomas P. Olson
  • Publication number: 20160151016
    Abstract: A method of pattern recognition for defining aerobic HR training zones measured during incremental cardiopulmonary exercise testing wherein such HR training zones are derived from distinct points in the incremental exercise response for % fat, % CHO, and PetCO2. Also disclosed is a method for providing feedback to the exercising subject indicating the % time the subject exercised in each of the zones using recorded HR data from each workout.
    Type: Application
    Filed: June 18, 2014
    Publication date: June 2, 2016
    Inventors: Stephen T. Anderson, David Anderson, Bruce D. Johnson, Dianna Orr