Patents by Inventor Bruce E. Gerlitz

Bruce E. Gerlitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vectors and compounds for expression of glycosylation mutants of human protein C
    Patent number: 5460953
    Abstract: A method for the recombinant production of forms of human protein C with higher activity is described. These forms differ from native protein C in their increased amidolytic and functional activities and novel carbohydrate structures. DNA compounds, vectors, and transformants useful in the method are also disclosed.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: October 24, 1995
    Assignee: Eli Lilly and Company
    Inventors: Bruce E. Gerlitz, Brian W. Grinnell
  • Protein C derivatives
    Patent number: 5453373
    Abstract: Human protein C derivatives with high activity and reduced dependence on thrombin activation are described. These derivatives differ from the native forms of human protein C in their increased activation rates, functional activities and carbohydrate structures. DNA compounds, transfer vectors, expression vectors and transformants useful in producing these derivatives are also described.
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: September 26, 1995
    Assignee: Eli Lilly and Company
    Inventors: Bruce E. Gerlitz, Brian W. Grinnell
  • Vectors and compounds for expression of zymogen forms of human protein C
    Patent number: 5270178
    Abstract: A method for the recombinant production of zymogen forms of human protein C is described. These zymogen forms differ from native zymogen protein C in their increased sensitivity to activation by thrombin and thrombin/thrombomodulin. DNA compounds, vectors, and transformants useful in the method are also disclosed.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: December 14, 1993
    Assignee: Eli Lilly and Company
    Inventors: Bruce E. Gerlitz, Brian W. Grinnell