Patents by Inventor Bruce E. Partridge

Bruce E. Partridge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
    Patent number: 6410707
    Abstract: A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: June 25, 2002
    Assignee: BioNebraska, Inc.
    Inventors: Fred W. Wagner, Jay S. Stout, Dennis B. Henriksen, Bruce E. Partridge, Bart Holmquist, Julie A. Frank
  • Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
    Publication number: 20010031856
    Abstract: A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
    Type: Application
    Filed: January 2, 2001
    Publication date: October 18, 2001
    Applicant: Bio Nebraska, Inc.
    Inventors: Fred W. Wagner, Jay S. Stout, Dennis B. Henriksen, Bruce E. Partridge, Bart Holmquist, Julie A. Frank
  • Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
    Patent number: 6251635
    Abstract: A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: June 26, 2001
    Assignee: Bionebraska, Inc.
    Inventors: Fred W. Wagner, Jay S. Stout, Dennis B. Henriksen, Bruce E. Partridge, Bart Holmquist, Julie A. Frank
  • Production of C-terminal amidated peptides from recombinant protein constructs
    Patent number: 6051399
    Abstract: A method for the production of C-terminal amidated recombinant peptides is provided. The method employs a recombinant protein construct having multiple copies of a target peptide linked by intraconnecting peptides. The intraconnecting peptides permit the multicopy construct to be selectively reacted to produce product peptides having a C-terminal .alpha.-carboxamide. A recombinant gene containing a DNA sequence coding for the recombinant protein construct and an expression cassette, an expression vector and a transformed cell including the recombinant gene are also provided.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: April 18, 2000
    Assignee: BioNebraska, Inc.
    Inventors: Jay S. Stout, Bruce E. Partridge, Dennis B. Henriksen, Barton Holmquist, Fred W. Wagner
  • Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
    Patent number: 5962270
    Abstract: A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: October 5, 1999
    Assignee: Bionebraska, Inc.
    Inventors: Fred W. Wagner, Jay S. Stout, Dennis B. Henriksen, Bruce E. Partridge, Bart Holmquist, Julie A. Frank
  • Treatment process for promoting weight loss employing a substituted .DELTA. 5
    Patent number: 5296481
    Abstract: A method for controlling weight gain or promoting weight loss which includes the step of treating a subject with an effective weight gain controlling or weight loss promoting amount of a substituted .DELTA.5-Androstene which is biologically effective for controlling weight gain or promoting weight loss and biologically ineffective for promoting the synthesis of sex hormones. Steroids believed to provide the desired weight control/weight loss characteristics include:.DELTA.5-Androstene-3.beta.,7.alpha.-diol-17-one.DELTA.5-Androstene-3.beta.-ol-7,17-dione.DELTA.5-Androstene-3.beta.,7.alpha.,17-triol.DELTA.5-Androstene-3.beta.,17.beta.-diol-7-oneand various derivatives thereof.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: March 22, 1994
    Assignee: Humanetics Corporation
    Inventors: Bruce E. Partridge, Henry A. Lardy