Patents by Inventor Bruce E. Vogel

Bruce E. Vogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detection of fibronectin receptor ligands
    Patent number: 5591592
    Abstract: The present invention provides a substantially pure integrin characterized in that it consists of an .alpha..sub.v and a .beta..sub.1 subunit. The receptor binds to fibronectin and GRGDSPK but does not bind to vitronectin. The .alpha..sub.v .beta..sub.1 receptor can be used to determine the presence of ligands for the receptor.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: January 7, 1997
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Erkki I. Ruoslahti, Guido Tarone, Filippo G. Giancotti, Bruce E. Vogel
  • Fibronectin receptor
    Patent number: 5169930
    Abstract: The present invention provides a substantially pure integrin-type receptor characterized in that it consists of an .alpha..sub.v and a .beta..sub.1 subunit. The .alpha..sub.v .beta..sub.1 integrin binds to fibronectin and GRGDSPK but does not bind to vitronectin. The .alpha..sub.v .beta..sub.1 integrin can be used to determine the presence of a .alpha..sub.v .beta..sub.1 ligand and to develop adhesion peptides specific for the various integrins. The presence of the .alpha..sub.v .beta..sub.1 integrin can be used to assess ability of cells to adhere to fibronectin.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: December 8, 1992
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Erkki I. Ruoslahti, Guido Tarone, Filippo G. Giancotti, Bruce E. Vogel