Patents by Inventor Bruce Edward Markham

Bruce Edward Markham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF DIABETES USING AGONISTS OF THE MAS-RELATED GPCR D
    Publication number: 20180074053
    Abstract: Methods of identifying agonists of MRGD for treating prediabetes, type-2 diabetes and cardiovascular diseases or disorders. Methods of treating prediabetes, type-2 diabetes and cardiovascular diseases or disorders comprising administering to a subject an agonist of MRGD.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 15, 2018
    Inventors: Zhongmin Ma, Bruce Edward Markham
  • Treatment of chronic progressive heart failure
    Patent number: 9155758
    Abstract: The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188).
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 13, 2015
    Assignee: PHRIXUS PHARMACEUTICALS, INC.
    Inventor: Bruce Edward Markham
  • POLOXAMERS FOR THE IMPROVEMENT OF RESPIRATORY FUNCTION
    Publication number: 20150190421
    Abstract: Methods for treating or preventing a respiratory deficiency associated with a diaphragm muscle deficiency in a subject are provided, the method comprises administering to the subject in need thereof, a therapeutically effective amount of a poloxamer, for example, poloxamer P-188.
    Type: Application
    Filed: July 18, 2013
    Publication date: July 9, 2015
    Inventor: Bruce Edward Markham
  • Compositions and methods for the treatment of heart failure
    Patent number: 8372387
    Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that improves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: February 12, 2013
    Assignee: Phrixus Pharmaceuticals, Inc.
    Inventor: Bruce Edward Markham
  • Compositions and Methods for the Treatment of Heart Failure
    Publication number: 20100178269
    Abstract: The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that improves the functioning of a diseased heart by decreasing left ventricular end-diastolic pressure and simultaneously increasing left ventricular ejection without affecting the blood pressure or heart rate.
    Type: Application
    Filed: April 4, 2008
    Publication date: July 15, 2010
    Applicant: Phrixus Pharmaceuticals , Inc.
    Inventor: Bruce Edward Markham
  • Treatment of Chronic Progressive Heart Failure
    Publication number: 20090246162
    Abstract: The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188).
    Type: Application
    Filed: August 1, 2007
    Publication date: October 1, 2009
    Inventor: Bruce Edward Markham