Patents by Inventor Bruce F. Molino

Bruce F. Molino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090118260
    Abstract: The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
    Type: Application
    Filed: October 16, 2008
    Publication date: May 7, 2009
    Applicants: AMR TECHNOLOGY, INC., BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Bruce F. MOLINO, Shuang LIU, Aruna SAMBANDAM, Peter R. GUZZO, Min HU, Congxiang ZHA, Kassoum NACRO, David D. MANNING, Matthew L. ISHERWOOD, Kristen N. FLEMING, Wenge CUI, Richard E. OLSON
  • Patent number: 7511013
    Abstract: The compounds of the present invention are represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: March 31, 2009
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • Publication number: 20090048443
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle opt
    Type: Application
    Filed: October 16, 2008
    Publication date: February 19, 2009
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Bruce F. MOLINO, Shuang LIU, Peter R. GUZZO, James P. BECK
  • Publication number: 20080249002
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Application
    Filed: April 15, 2008
    Publication date: October 9, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Bruce F. Molino, Zhicai Yang
  • Patent number: 7410968
    Abstract: The present invention relates to compounds represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: August 12, 2008
    Assignee: PARION SCIENCES, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Publication number: 20080176863
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Publication number: 20080167466
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 10, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Publication number: 20080153744
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, Ro, and R1 defined herein.
    Type: Application
    Filed: March 12, 2008
    Publication date: June 26, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Bruce F. Molino, Zhicai YANG
  • Patent number: 7388013
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: June 17, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Patent number: 7378391
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: May 27, 2008
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • Patent number: 7368451
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Patent number: 7368447
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 6, 2008
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Patent number: 7361636
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 22, 2008
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • Patent number: 7247637
    Abstract: The present invention relates to a compound represented by formula (I): where the structural variables are as defined herein. The compound is useful for promoting hydration of mucosal surfaces.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: July 24, 2007
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Bruce F. Molino, Jianzhong Zhang, Bruce Sargent
  • Publication number: 20040235716
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: 1 Formula I 1
    Type: Application
    Filed: March 16, 2004
    Publication date: November 25, 2004
    Inventors: Bruce F. Molino, Simon N. Haydar, Zhicai Yang, Peter C. Michels, Michael S. Hemenway, Joseph O. Rich, Yuri Khmelnitsky
  • Patent number: 6797700
    Abstract: The present invention relates to peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and dissembulated intravascular coagulation.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: September 28, 2004
    Assignee: Aventis Pharmaceuticals, Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Publication number: 20020002268
    Abstract: The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: July 12, 2001
    Publication date: January 3, 2002
    Inventors: Scott I. Klein, Bruce F. Molino
  • Patent number: 6274705
    Abstract: The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: August 14, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Patent number: 5866685
    Abstract: The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: February 2, 1999
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Patent number: 5780590
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-?N-?N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl!-(L)-aspartyl!-(L)-.beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E.sup.1, E.sup.2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: July 14, 1998
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino, Mark Czekaj, Charles J. Gardner