Patents by Inventor Bruce Fleck

Bruce Fleck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTRODUCER TACTILE FEATURE
    Publication number: 20130345660
    Abstract: An introduction system and method of use is provided. The introduction system includes a catheter assembly, a member, and a tactile indicator. The member is configured to be introduced through the catheter assembly and the tactile indicator is configured to provide a tactile sensory input when the member reaches a predetermined position relative to the catheter assembly. As such, the tactile indicator provides increased resistance to the relative motion between the member and catheter assembly when the member reaches the predetermined position.
    Type: Application
    Filed: August 29, 2013
    Publication date: December 26, 2013
    Applicant: Cook Incorporated
    Inventors: James J. Kennedy, III, Mark R. Frye, Bruce Fleck
  • (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine and salts thereof
    Patent number: 8410113
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: April 2, 2013
    Assignee: Biovitrum AB (publ)
    Inventors: Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren, Bruce Fleck
  • (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE AND SALTS THEREOF
    Publication number: 20120010410
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 12, 2012
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • SUCCINATE SALT OF (2R)-METHYL-1-PIPERAZINE
    Publication number: 20120004241
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 5, 2012
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Malate salt of (2R)-methyl-1-{3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinyl}piperazine
    Patent number: 8030316
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: October 4, 2011
    Assignee: Biovitrum AB (Publ)
    Inventors: Tom Fleck, Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Phosphoric acid addition salt of (2R)-1-[3-(2-{[2-(2-dimethylaminoethoxy)-3-pyridinyl]oxy}-ethoxy)-2-pyrazinyl]-2-methylpiperazine
    Patent number: 7820677
    Abstract: Stable acid addition salts of certain 2,3-disubstituted pyrazine compounds that are selective for the 5-HT2c receptor and therapeutically active in the central nervous system are described.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: October 26, 2010
    Inventors: Tom Fleck, Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • NOVEL PROCESS
    Publication number: 20100256374
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: June 17, 2010
    Publication date: October 7, 2010
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Process for the preparation of stable acid addition salt of 2,3-disubstituted pyrazine compounds
    Patent number: 7129354
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R1–R4 are each independently selected from the group consisting of hydrogen, halogen, C1–C6-alkyl, C1–C6-alkoxy, and di-C1–C6-alkylamino-C2–C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: October 31, 2006
    Assignee: Biovitrum AB
    Inventors: Bruce Fleck, legal representative, Magnus Cernerud, Helena Lundström, Claes Löfström, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren, Tom Fleck, deceased
  • Introducer tactile feature
    Publication number: 20060190005
    Abstract: An introduction system and method of use is provided. The introduction system includes a catheter assembly, a member, and a tactile indicator. The member is configured to be introduced through the catheter assembly and the tactile indicator is configured to provide a tactile sensory input when the member reaches a predetermined position relative to the catheter assembly. As such, the tactile indicator provides increased resistance to the relative motion between the member and catheter assembly when the member reaches the predetermined position.
    Type: Application
    Filed: December 28, 2005
    Publication date: August 24, 2006
    Applicant: Cook Incorporated
    Inventors: James Kennedy, Mark Frye, Bruce Fleck
  • Novel process
    Publication number: 20060142578
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. (I)n one aspect, the invention relates to a process for the preparation of compounds of the general formula ((I)): wherein HA is a pharmaceutically acceptable acid and R1-R4 are each independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, and di-C1-C6-alkylamino-C2-C6-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.
    Type: Application
    Filed: February 22, 2006
    Publication date: June 29, 2006
    Inventors: Tom Fleck, Bruce Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Andersson, Alf Nygren
  • Novel Process
    Publication number: 20040038981
    Abstract: The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system.
    Type: Application
    Filed: June 18, 2003
    Publication date: February 26, 2004
    Inventors: Bruce Fleck, Tom Fleck, Magnus Cernerud, Helena Lundstrom, Claes Lofstrom, Margit Pelcman, Alexander Paptchikhine, Emma Andrersson, Alf Nygren