Abstract: In general, the systems and methods described in this application relate to laser-induced nucleation in continuous flow. A method of laser-induced nucleation in continuous flow includes injecting a saturated solution, undersaturated solution, or supersaturated solution through an inlet of a device. The method can include converting the saturated solution or undersaturated solution into supersaturated solution by changing a temperature of the saturated solution or undersaturated solution. The method can include passing one or more laser pulses through the supersaturated solution within the device. The method can include flowing the saturated solution, undersaturated solution, or the supersaturated solution through an outlet of the device.

Abstract: In general, the systems and methods described in this application relate to laser-induced nucleation in continuous flow. A method of laser-induced nucleation in continuous flow includes injecting a saturated solution, undersaturated solution, or supersaturated solution through an inlet of a device. The method can include converting the saturated solution or undersaturated solution into supersaturated solution by changing a temperature of the saturated solution or undersaturated solution. The method can include passing one or more laser pulses through the supersaturated solution within the device. The method can include flowing the saturated solution, undersaturated solution, or the supersaturated solution through an outlet of the device.

Abstract: Applying a strong static DC electric field to supersaturated aqueous glycine solutions resulted in the nucleation of the ? polymorph attributed to the electric-field induced orientation of the highly polar glycine molecules in large preexisting solute clusters, helping them organize into a crystalline structure. A method to induce crystallization and to prepare polymorphs and/or morphologies of materials by using a static electric field to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure that would not normally appear without the use of the static electric field. Aqueous glycine solutions were prepared by combining solid glycine and water. Supersaturated solutions were generated by heating the tubes to 62-64° C. and holding them at that temperature in an ultrasonicator overnight. Once the glycine was completely dissolved, the solutions were slowly cooled to room temperature.

Abstract: A method and device for automatically detecting the onset of a hot flash while the subject is sleeping, and of cooling the subject using a cold fluid circulating through a vest or a mattress pad, before sweating and/or chills develop and awaken the subject. A temperature sensor is attached to the subject's skin, and is connected to a computer or microprocessor. The subject dons a vest that is connected to a coolant circulation system. Alternatively, the subject lies on a mattress pad that is connected to a coolant circulation system. During the night, if the subject's skin temperature rises more than a predetermined amount within a time period, or rises above a predetermined threshold temperature, the coolant circulation system is activated for a fixed period of time. The cooled vest or pad helps to draw heat away from the subject's skin and thus reduce the symptoms of the hot flash. After the circulation terminates, the system is reset to monitor the skin temperature once again.

Abstract: A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure which would not normally appear without the use of the laser.

Abstract: Applying a strong static DC electric field to supersaturated aqueous glycine solutions resulted in the nucleation of the ? polymorph attributed to the electric-field induced orientation of the highly polar glycine molecules in large preexisting solute clusters, helping them organize into a crystalline structure. A method to induce crystallization and to prepare polymorphs and/or morphologies of materials by using a static electric field to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure that would not normally appear without the use of the static electric field. Aqueous glycine solutions were prepared by combining solid glycine and water. Supersaturated solutions were generated by heating the tubes to 62-64° C. and holding them at that temperature in an ultrasonicator overnight. Once the glycine was completely dissolved, the solutions were slowly cooled to room temperature.

Abstract: A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation.

Abstract: A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure which would not normally appear without the use of the laser.

Abstract: A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation.

Abstract: A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supersaturated solution in such a way as to obtain a crystal structure which would not normally appear without the use of the laser.