Abstract: There is disclosed device and method provide efficient, comfortable and accurate positioning of a treatment device relative to a specific cranial anatomical location of a subject. In an embodiment, the method comprises: placing a fixed-position locating device on the cranium of the subject; placing an adjustable positioning cap on the cranium of the subject; loading a subject-specific calibration for treatment of a specified cranial anatomical location; determining a three-dimensional position of the fixed-position locator device relative to the adjustable positioning cap; and calibrating the location of the positioning cap by adjusting the positioning cap until it is aligned with the specified cranial anatomical location.