Patents by Inventor Bruce Ivins

Bruce Ivins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
    Patent number: 8481055
    Abstract: The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 9, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Bruce Ivins, Daniela Verthelyi
  • METHOD OF PREVENTING INFECTIONS FROM BIOTERRORISM AGENTS WITH IMMUNOSTIMULATORY CPG OLIGONUCLEOTIDES
    Publication number: 20100226941
    Abstract: The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
    Type: Application
    Filed: May 24, 2010
    Publication date: September 9, 2010
    Inventors: Dennis M. Klinman, Bruce Ivins, Daniela Verthelyi
  • Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides
    Patent number: 7758876
    Abstract: The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: July 20, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Bruce Ivins, Daniela Verthelyi
  • Method of preventing infections from bioterrorism agents with immunostimulatory cpg oligonucleotides
    Publication number: 20060019239
    Abstract: The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
    Type: Application
    Filed: October 31, 2003
    Publication date: January 26, 2006
    Inventors: Bruce Ivins, Daniela Verthelyi
  • Method of making a vaccine for anthrax
    Patent number: 6387665
    Abstract: A method of making a vaccine for anthracis that inolves a bacterial expression system and production and use of protective antigen (PA) against Bacillus anthracis. The PA immunogen is useful in a vaccine against human anthrax. The PA can be produced by an asporogenic organism which produces the desired antigen, which is then harvested from the supernatant.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: May 14, 2002
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Bruce Ivins, Patricia Worsham, Arthur M. Friedlander, Joseph W. Farchaus, Susan L. Welkos
  • METHOD OF MAKING A VACCINE
    Publication number: 20020034512
    Abstract: A method of making a vaccine from a protective antigen. The protective antigen is useful against Bacillus anthracis. The protective antigenis produced by an asporogenic organism which overpoduces the desired antigen. The asporogenic organism is a recombinant asporogenic B. anthracis. The recombinant asporogenic B. anthracis was derived from a &Dgr;Sterne-1(pPA102) strain of bacteria and binds to dye when grown on Congo Red Agar.
    Type: Application
    Filed: March 7, 2000
    Publication date: March 21, 2002
    Inventors: Bruce Ivins, Patricia Worsham, Arthur M Friedlander, Joseph W Farchaus, Susan L Welkos
  • Asporogenic B anthracis expression system
    Patent number: 6316006
    Abstract: This invention relates to a bacterial expression system for production of protective antigen (PA) against bacillus anthracis. Recombinant asporogenic B. anthracits that are derived from &Dgr;Sterne-1(pPA102) and show inability to bind the dye when grown on Congo Red Agar can be screened and asporogenic strains isolated using methods of the invention. organisms of the invention lacking spore-forming function may be killed by heat shock at temperatures as low as 60° C. for 60 minutes. Hence, contamination of the environment with viable spore-forming organisms is easily avoided and decontamination is easily accomplished.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: November 13, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Patricia Worsham, Arthur M. Friedlander, Bruce Ivins