Patents by Inventor Bruce J. Aungst

Bruce J. Aungst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations of cyclic urea type compounds
    Patent number: 5559110
    Abstract: Compositions comprising a cyclic urea type compound in a liquid or solid vehicle comprising a fatty acid ester of glycerol, or a fatty acid ester of polyethylene glycol, or a mixture thereof, wherein said vehicle has an hydrophil-lipophil balance of at least about 10, and, optionally, other excipients are described. The compositions are useful for providing good systemic absorption of the cyclic urea compounds when administered enterally, especially orally. The subject compounds and compositions are useful for treating viral infections, particularly HIV infection, in a mammal.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: September 24, 1996
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventor: Bruce J. Aungst
  • Topical antinflammatory compositions with minimal systemic absorption
    Patent number: 5091379
    Abstract: Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: February 25, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventor: Bruce J. Aungst
  • Substituted benzoate ester prodrugs of estrogens
    Patent number: 4757062
    Abstract: Substituted benzoate ester prodrugs of .beta.-estradiol and ethynyl estradiol are provided which have improved bioavailability and extended duration of action when administered orally.
    Type: Grant
    Filed: November 1, 1985
    Date of Patent: July 12, 1988
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Bruce J. Aungst, Munir A. Hussain
  • Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
    Patent number: 4673679
    Abstract: Aliphatic, aromatic, carbonate, carbamate, or sulfonate ester prodrugs of 3-hydroxymorphinans lack the bitter taste of the parent compounds and provide enhanced bioavailability of 3-hydroxymorphinans from buccal, nasal, and sublingual dosage forms.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: June 16, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Bruce J. Aungst, Munir A. Hussain