Patents by Inventor Bruce J. Gluckman

Bruce J. Gluckman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11744508
    Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: September 5, 2023
    Assignee: The Penn State Research Foundation
    Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
  • Patent number: 11730951
    Abstract: The present invention provides devices and methods for modulating spreading depression in the brain.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 22, 2023
    Assignee: The Penn State Research Foundation
    Inventors: Steven J. Schiff, Bruce J. Gluckman, Andrew J. Whalen
  • Publication number: 20210401356
    Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
    Type: Application
    Filed: September 7, 2021
    Publication date: December 30, 2021
    Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
  • Patent number: 11141097
    Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 12, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
  • Publication number: 20200297994
    Abstract: The present invention provides devices and methods for modulating spreading depression in the brain.
    Type: Application
    Filed: November 9, 2018
    Publication date: September 24, 2020
    Inventors: Steven J. Schiff, Bruce J. Gluckman, Andrew J. Whalen
  • Publication number: 20190328306
    Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 31, 2019
    Applicant: The Penn State Research Foundation
    Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
  • Patent number: 9592378
    Abstract: Biocompatible electrodes with smaller geometric area improve the selectivity of the neural recording and stimulation applications. A volume within the electrode back plane of a micro-reaction chamber (?RC) is used to confine and sequester an electrochemical reaction used for charge passage. The ?RC electrode decreases impedance and improves charge storage capacity without altering the geometry of the active site.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: March 14, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Bruce J. Gluckman, Balaji Shanmugasundaram
  • Publication number: 20130053934
    Abstract: Biocompatible electrodes with smaller geometric area improve the selectivity of the neural recording and stimulation applications. A volume within the electrode back plane of a micro-reaction chamber (?RC) is used to confine and sequester an electrochemical reaction used for charge passage. The ?RC electrode decreases impedance and improves charge storage capacity without altering the geometry of the active site.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 28, 2013
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Bruce J. Gluckman, Balaji Shanmugasundaram
  • Patent number: 6873872
    Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: March 29, 2005
    Assignee: George Mason University
    Inventors: Bruce J. Gluckman, Steven J. Schiff
  • Publication number: 20040073273
    Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 15, 2004
    Inventors: Bruce J. Gluckman, Steven J. Schiff
  • Patent number: 6665562
    Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to the neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of the applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: December 16, 2003
    Assignee: George Mason University
    Inventors: Bruce J. Gluckman, Steven J. Schiff
  • Publication number: 20030114886
    Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.
    Type: Application
    Filed: October 11, 2002
    Publication date: June 19, 2003
    Inventors: Bruce J. Gluckman, Steven J. Schiff
  • Publication number: 20010029391
    Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.
    Type: Application
    Filed: December 6, 2000
    Publication date: October 11, 2001
    Applicant: George Mason University
    Inventors: Bruce J. Gluckman, Steven J. Schiff
  • Patent number: 5800459
    Abstract: A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electric field is controllably changed in polarity and magnitude to modify such epileptic activity based on data obtained by recording such activity through electrodes that are isopotentially aligned within the electric field imposed on a slice of the brain tissue.
    Type: Grant
    Filed: December 24, 1996
    Date of Patent: September 1, 1998
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Mark L. Spano, Steven J. Schiff, Bruce J. Gluckman, William L. Ditto
  • Patent number: 5797965
    Abstract: A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electrical field is controllably varied in magnitude to suppress such epilieptic activity.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: August 25, 1998
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Mark L. Spano, Steven J. Schiff, Bruce J. Gluckman, William L. Ditto