Patents by Inventor Bruce J. Gluckman
Bruce J. Gluckman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11744508Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.Type: GrantFiled: September 7, 2021Date of Patent: September 5, 2023Assignee: The Penn State Research FoundationInventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
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Patent number: 11730951Abstract: The present invention provides devices and methods for modulating spreading depression in the brain.Type: GrantFiled: November 9, 2018Date of Patent: August 22, 2023Assignee: The Penn State Research FoundationInventors: Steven J. Schiff, Bruce J. Gluckman, Andrew J. Whalen
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Publication number: 20210401356Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.Type: ApplicationFiled: September 7, 2021Publication date: December 30, 2021Inventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
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Patent number: 11141097Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.Type: GrantFiled: April 26, 2019Date of Patent: October 12, 2021Assignee: The Penn State Research FoundationInventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
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Publication number: 20200297994Abstract: The present invention provides devices and methods for modulating spreading depression in the brain.Type: ApplicationFiled: November 9, 2018Publication date: September 24, 2020Inventors: Steven J. Schiff, Bruce J. Gluckman, Andrew J. Whalen
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Publication number: 20190328306Abstract: Systems, methods, and other techniques for monitoring, including non-invasive monitoring, of biological markers based on the interaction, temporal association, or coincidence of brain activity and periphery activity in a mammal are provided. Systems and methods for generating a behavioral state-independent representation of cardiac activity and for identifying cardiac events and/or brain-periphery, e.g., brain-cardiac, temporal associations useful as biomarkers of disease such as, e.g., neurologic disease, in a mammal are also provided.Type: ApplicationFiled: April 26, 2019Publication date: October 31, 2019Applicant: The Penn State Research FoundationInventors: Bruce J. Gluckman, Fatemeh Bahari, Steven J. Schiff
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Patent number: 9592378Abstract: Biocompatible electrodes with smaller geometric area improve the selectivity of the neural recording and stimulation applications. A volume within the electrode back plane of a micro-reaction chamber (?RC) is used to confine and sequester an electrochemical reaction used for charge passage. The ?RC electrode decreases impedance and improves charge storage capacity without altering the geometry of the active site.Type: GrantFiled: August 27, 2012Date of Patent: March 14, 2017Assignee: THE PENN STATE RESEARCH FOUNDATIONInventors: Bruce J. Gluckman, Balaji Shanmugasundaram
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Publication number: 20130053934Abstract: Biocompatible electrodes with smaller geometric area improve the selectivity of the neural recording and stimulation applications. A volume within the electrode back plane of a micro-reaction chamber (?RC) is used to confine and sequester an electrochemical reaction used for charge passage. The ?RC electrode decreases impedance and improves charge storage capacity without altering the geometry of the active site.Type: ApplicationFiled: August 27, 2012Publication date: February 28, 2013Applicant: THE PENN STATE RESEARCH FOUNDATIONInventors: Bruce J. Gluckman, Balaji Shanmugasundaram
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Patent number: 6873872Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.Type: GrantFiled: October 11, 2002Date of Patent: March 29, 2005Assignee: George Mason UniversityInventors: Bruce J. Gluckman, Steven J. Schiff
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Publication number: 20040073273Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.Type: ApplicationFiled: October 6, 2003Publication date: April 15, 2004Inventors: Bruce J. Gluckman, Steven J. Schiff
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Patent number: 6665562Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to the neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of the applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.Type: GrantFiled: December 6, 2000Date of Patent: December 16, 2003Assignee: George Mason UniversityInventors: Bruce J. Gluckman, Steven J. Schiff
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Publication number: 20030114886Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.Type: ApplicationFiled: October 11, 2002Publication date: June 19, 2003Inventors: Bruce J. Gluckman, Steven J. Schiff
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Publication number: 20010029391Abstract: The present invention relates to devices and methods of modifying the neuronal activity of a neural system comprising neurons, comprising, one or more of the following steps, measuring the neuronal activity of a neural system; and applying an oriented electric field to said neural system effective to modify the neuronal activity of the neural system, wherein the magnitude and polarity of said applied electric field is changed in response to the measured neuronal activity. The present invention also relates to devices and methods for treating brain disorders, such as epilepsy and Parkinson's disease, comprising, one or more of the following steps, applying a sub-threshold and oriented electric field in situ to the brain of a patient having such a disorder in an amount effective to reduce the abnormal activity of the brain, wherein the electric field is applied through field electrodes in contact with the brain.Type: ApplicationFiled: December 6, 2000Publication date: October 11, 2001Applicant: George Mason UniversityInventors: Bruce J. Gluckman, Steven J. Schiff
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Patent number: 5800459Abstract: A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electric field is controllably changed in polarity and magnitude to modify such epileptic activity based on data obtained by recording such activity through electrodes that are isopotentially aligned within the electric field imposed on a slice of the brain tissue.Type: GrantFiled: December 24, 1996Date of Patent: September 1, 1998Assignee: The United States of America as represented by the Secretary of the NavyInventors: Mark L. Spano, Steven J. Schiff, Bruce J. Gluckman, William L. Ditto
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Patent number: 5797965Abstract: A DC electric field is applied to brain tissue in parallel alignment with urons thereof during periods of brief duration while the tissue is undergoing epileptic activity. The electrical field is controllably varied in magnitude to suppress such epilieptic activity.Type: GrantFiled: March 26, 1997Date of Patent: August 25, 1998Assignee: The United States of America as represented by the Secretary of the NavyInventors: Mark L. Spano, Steven J. Schiff, Bruce J. Gluckman, William L. Ditto