Patents by Inventor Bruce J. Holub

Bruce J. Holub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of fortifying seeds with an essential fatty acid, fortified seed and food product
    Patent number: 7416752
    Abstract: A method is provided for fortifying a seed, grain, nut, bean, or the like with an essential fatty acid such as docosahexaenoic acid or eicosapentaenoic acid. Using the method, it is possible to produce seeds that can be used as a dietary source of that essential fatty acid. A seed that has been soaked in an aqueous mixture containing an essential fatty acid so as to become fortified with the fatty acid, and a food product formed using the seed are also provided.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: August 26, 2008
    Assignee: Sharp Ingrained Functional Foods, Inc.
    Inventors: Bruce J. Holub, Arun Nagpurkar
  • Triterpene saponins from soybeans for treating kidney disease
    Patent number: 6784159
    Abstract: A method of treating polycystic kidney disease is described. The method involves administering soyasaponin Bb to an animal in need thereof.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: August 31, 2004
    Assignees: Her Majesty the Queen in right of Canada, as represented by the Minister of Agriculture, University of Guelph
    Inventors: Bruce J. Holub, F. William Collins, Dominique P. Bureau, Diana J. Philbrick
  • Method of detecting gynecological carcinomas
    Publication number: 20030113928
    Abstract: Methods for detecting or diagnosing gynecological carcinomas in a patient are provided. One method The method, which involves assaying for the presence of lysophosphatidic acid in a plasma sample of the patient, is useful for detecting ovarian carcinoma, cervical carcinoma, endometrial carcinoma, and peritoneal carcinoma. In a preferred embodiment the method comprises: providing a blood specimen from the patient, obtaining a plasma sample for the blood specimen under conditions which minimize the release of lysophosphatidic acid from the platelets in the blood specimen into the plasma, extracting lipids from the plasma, and detecting the presence of lysophosphatidic acid in the lipid. Another method involves assaying for the presence of lysophosphatidyl inositol in a bodily fluid, preferably plasma, from the subject.
    Type: Application
    Filed: July 24, 2002
    Publication date: June 19, 2003
    Inventors: Yan Xu, Graham Casey, Douglas C. Gaudette, Bruce J. Holub, Gordon B. Mills
  • Triterpene saponins from soybeans for treating kidney disease
    Publication number: 20020107209
    Abstract: A method of treating polycystic kidney disease is described. The method involves administering soyasaponin Bb to an animal in need thereof.
    Type: Application
    Filed: September 28, 2001
    Publication date: August 8, 2002
    Inventors: Bruce J. Holub, F. William Collins, Dominique P. Bureau, Diana J. Philbrick
  • Method of detecting gynecological carcinomas
    Patent number: 5994141
    Abstract: Methods for diagnosing and screening for ovarian carcinomas in a subject are provided The methods employ the steps of preparing a plasma sample from a blood specimen from the subject, and assaying for the presence of lysophosphatidic acid in the plasma sample. The presence of lysophosphatidic acid in the plasma sample is indicative of ovarian carcinoma in the subject. In a preferred embodiment the plasma sample is prepared under conditions which minimize the release of lysophosphatidic acid from platelets in the blood specimen into the plasma.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: November 30, 1999
    Assignee: The Cleveland Clinic Foundation
    Inventors: Yan Xu, Graham Casey, Douglas C. Gaudette, Bruce J. Holub, Gordon B. Mills
  • Method for enriching docosahexaenoic acid in expressed milk of dairy cattle
    Patent number: 5932257
    Abstract: A feed additive for dairy cattle is described comprising DHA and inhibitors of microbial degradation of DHA in the rumen of the dairy cattle. A method of producing milk in dairy cattle which is enriched for DHA is also described comprising feeding the dairy cattle a feed containing the feed additive of the invention for a period of at least about 14 day, and milking the dairy cattle to obtain milk enriched for DHA.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: August 3, 1999
    Assignee: University of Guelph
    Inventors: Thomas C. Wright, Brian McBride, Bruce J. Holub
  • Animal feed supplement
    Patent number: 5290573
    Abstract: Fish meal containing omega-3 unsaturated fatty acids is useful as a feed additive for beef cattle feed.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: March 1, 1994
    Inventor: Bruce J. Holub
  • Animal feed supplement
    Patent number: 4911944
    Abstract: Fish meal containing omega-3 unsaturated fatty acids is useful as a feed additive for beef cattle feed.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: March 27, 1990
    Inventor: Bruce J. Holub